Journal article
HIV and its relationship to insulin resistance and lipid abnormalities
Translational research : the journal of laboratory and clinical medicine, Vol.183, pp.41-56
05/2017
DOI: 10.1016/j.trsl.2016.12.007
PMID: 28068521
Abstract
Antiretroviral therapy has revolutionized the care of people with human immunodeficiency virus (HIV) by reducing morbidity and mortality from acquired immunodeficiency syndrome-related conditions. Despite longer life expectancy, however, HIV-infected individuals continue to have a higher risk of death compared with the general population. This has been attributed to the increasing incidence of noncommunicable diseases, in particular, atherosclerotic cardiovascular diseases. This is driven, in part, by the emergence of metabolic disorders, particularly dyslipidemia, insulin resistance, and lipodystrophy, in those on antiretroviral therapy. The pathogenesis of these metabolic derangements is complex and multifactorial, and could be a consequence of an interplay between traditional age-related risk factors, HIV infection, antiretroviral therapy effects, and the inflammatory state and immune activation in this population. Understanding the contributions of each of these factors could not just impact the current management of these individuals and help mitigate the risk for premature cardiovascular disease, but also shape the future direction of research in HIV.
Details
- Title: Subtitle
- HIV and its relationship to insulin resistance and lipid abnormalities
- Creators
- Lemuel R Non - Washington University in St. LouisGerome V Escota - Washington University in St. LouisWilliam G Powderly - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Translational research : the journal of laboratory and clinical medicine, Vol.183, pp.41-56
- DOI
- 10.1016/j.trsl.2016.12.007
- PMID
- 28068521
- ISSN
- 1931-5244
- eISSN
- 1878-1810
- Language
- English
- Date published
- 05/2017
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9984359688202771
Metrics
12 Record Views