HIV interactions with monocytes and dendritic cells: viral latency and reservoirs

Christopher M Coleman; Li Wu

doi:10.1186/1742-4690-6-51

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HIV interactions with monocytes and dendritic cells: viral latency and reservoirs

Journal article

Open access

Peer reviewed

HIV interactions with monocytes and dendritic cells: viral latency and reservoirs

Christopher M Coleman and Li Wu

Retrovirology, Vol.6(1), pp.51-51

06/01/2009

DOI: 10.1186/1742-4690-6-51

PMCID: PMC2697150

PMID: 19486514

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Abstract

HIV is a devastating human pathogen that causes serious immunological diseases in humans around the world. The virus is able to remain latent in an infected host for many years, allowing for the long-term survival of the virus and inevitably prolonging the infection process. The location and mechanisms of HIV latency are under investigation and remain important topics in the study of viral pathogenesis. Given that HIV is a blood-borne pathogen, a number of cell types have been proposed to be the sites of latency, including resting memory CD4+ T cells, peripheral blood monocytes, dendritic cells and macrophages in the lymph nodes, and haematopoietic stem cells in the bone marrow. This review updates the latest advances in the study of HIV interactions with monocytes and dendritic cells, and highlights the potential role of these cells as viral reservoirs and the effects of the HIV-host-cell interactions on viral pathogenesis.

HIV Infections - immunology

Monocytes - virology

HIV - physiology

Virus Latency

HIV Infections - virology

Humans

HIV - immunology

Dendritic Cells - virology

Details

Title: Subtitle: HIV interactions with monocytes and dendritic cells: viral latency and reservoirs
Creators: Christopher M Coleman - Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. ccoleman@mcw.edu
Li Wu
Resource Type: Journal article
Publication Details: Retrovirology, Vol.6(1), pp.51-51
DOI: 10.1186/1742-4690-6-51
PMID: 19486514
PMCID: PMC2697150
NLM abbreviation: Retrovirology
ISSN: 1742-4690
eISSN: 1742-4690
Publisher: England
Grant note: R21 AI078762 / NIAID NIH HHS R21 AI078762-01 / NIAID NIH HHS R01 AI068493 / NIAID NIH HHS R01 AI068493-04 / NIAID NIH HHS AI068493 / NIAID NIH HHS AI078762 / NIAID NIH HHS
Language: English
Date published: 06/01/2009
Academic Unit: Microbiology and Immunology
Record Identifier: 9984001126802771

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