Journal article
HIV type 1 variants with nevirapine resistance mutations are rarely detected in antiretroviral drug-naive african women with subtypes A, C, and D
AIDS research and human retroviruses, Vol.23(6), pp.764-768
2007
DOI: 10.1089/aid.2006.0272
PMID: 17604538
Abstract
K103N is frequently detected in HIV-infected women after single dose (SD) nevirapine (NVP). K103N-containing variants were detected more frequently by the ViroSeq HIV-1 Genotyping System in women with subtype C (69.2%) than subtypes A (19.4%, p < 0.0001) or D (36.1%, p < 0.0001). K103N-containing variants were also detected more frequently and at higher levels in women with subtype C by the LigAmp assay. In this report, we analyzed samples collected prior to or within hours after SD NVP administration from antiretroviral drug-naive African women with subtypes A, C, and D. Only 1/254 samples had an NVP resistance mutation detected with the ViroSeq system, and only 4/236 samples had K103N detected at < 0.5% with the LigAmp assay [2/110 (1.8%) with subtype A, 1/46 (2.2%) with subtype C, and 1/80 (1.3%) with subtype D] (p = 0.92). We did not detect significant differences in the pre-NVP frequency of NVP resistance mutations or the pre-NVP levels of K103N-containing variants in women with subtypes A, C, and D that explain the dramatic subtype-based differences in emergence of HIV-1 variants with these mutations after SD NVP exposure.
Details
- Title: Subtitle
- HIV type 1 variants with nevirapine resistance mutations are rarely detected in antiretroviral drug-naive african women with subtypes A, C, and D
- Creators
- Jessica D CHURCH - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United StatesSarah E HUDELSON - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United StatesJ. Brooks JACKSON - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United StatesTaha E TAHA - Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, United StatesSusan H ESHLEMAN - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United StatesLaura A GUAY - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United StatesShu Chen - Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, United StatesDonald R HOOVER - Department of Statistics and Institute for Health, Health Care Policy and Aging Research, Rutgers University, Piscataway, New Jersey 08854, United StatesNeil PARKIN - Monogram Biosciences, South San Francisco, California 94080, United StatesSusan A FISCUS - Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United StatesFrancis MMIRO - Department of Obstetrics and Gynaecology, Makerere University, Kampala, UgandaPhilippa MUSOKE - Department of Paediatrics, Makerere University, Kampala, UgandaNewton KUMWENDA - Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, United States
- Resource Type
- Journal article
- Publication Details
- AIDS research and human retroviruses, Vol.23(6), pp.764-768
- Publisher
- Liebert; Larchmont, NY
- DOI
- 10.1089/aid.2006.0272
- PMID
- 17604538
- ISSN
- 0889-2229
- eISSN
- 1931-8405
- Language
- English
- Date published
- 2007
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047622102771
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