Journal article
HLA-B7 and HLA-DR2 antigens and acute posterior multifocal placoid pigment epitheliopathy
Archives of ophthalmology (1960), Vol.108(5), pp.698-700
05/1990
DOI: 10.1001/archopht.1990.01070070084040
PMID: 2334328
Abstract
Acute posterior multifocal placoid pigment epitheliopathy is a chorioretinal inflammatory disease occurring in young, healthy adults. Its cause is unknown, although it frequently follows a flulike illness. We reexamined 30 patients with documented acute posterior multifocal placoid pigment epitheliopathy to determine their HLA class I antigen (A and B) and class II antigen (DR and DQ) distribution. The HLA class I antigen B7 was found in 12 patients (40.0%) compared with 63 controls (16.6%) (relative risk, 3.38). The class II antigen DR2 was present in 17 patients (56.7%) compared with 107 controls (28.2%) (relative risk, 3.34). The specific role of HLA antigens in uveitis is unknown, but the finding of an increased prevalence of HLA-B7 and HLA-DR2 antigens in patients with acute posterior multifocal placoid pigment epitheliopathy suggests an immunogenetic predisposition to acquiring this disease.
Details
- Title: Subtitle
- HLA-B7 and HLA-DR2 antigens and acute posterior multifocal placoid pigment epitheliopathy
- Creators
- M D Wolf - Department of Ophthalmology, University of Iowa, Iowa CityJ C FolkC A PanknenN E Goeken
- Resource Type
- Journal article
- Publication Details
- Archives of ophthalmology (1960), Vol.108(5), pp.698-700
- DOI
- 10.1001/archopht.1990.01070070084040
- PMID
- 2334328
- NLM abbreviation
- Arch Ophthalmol
- ISSN
- 0003-9950
- eISSN
- 1538-3601
- Publisher
- American Medical Association; United States
- Language
- English
- Date published
- 05/1990
- Academic Unit
- Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980291302771
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