Journal article
HLA DQA1-DQB1 genotypes in Bedouin families with celiac disease
Human immunology, Vol.63(6), pp.502-507
2002
DOI: 10.1016/S0198-8859(02)00395-6
PMID: 12039527
Abstract
Celiac disease (CD) has a strong genetic association with human leukocyte antigens (HLA). The primary susceptibility for CD is HLA-
DQA1*05 DQB1*02 (also known as DQ2), with the remainder of cases primarily HLA-
DQA1*03 DQB1*03 (also known as DQ8). In a set of nine Bedouin multiplex celiac disease families and one simplex, we genotyped DNA samples at HLA
DQA1 and
DQB1. Nineteen celiac disease patients had at least one
DQA1*05
DQB1*02 genotype (= DQ2), 4 affecteds had the second most common genotype of
DQA1*03
DQB1*0302 (= DQ8), 9 were DQ2 and DQ8, and 4 had at least one copy of
DQB1*02 without the
DQA1*05 genotype. Using transmission disequilibrium testing, we observed a significant over-representation in affecteds of the
DQA1*05
DQB1*02 genotype (
p = 0.0089), as well as over-representation of the
DQA1*03
DQB1*0302 genotype (
p = 0.078). The HLA
DQA1 DQB1 high-risk genotypes associated with celiac disease are similar in these Bedouin families with CD to what is observed in Northern and Southern Europeans.
Details
- Title: Subtitle
- HLA DQA1-DQB1 genotypes in Bedouin families with celiac disease
- Creators
- Susan L Neuhausen - Department of Medical Informatics (S.L.N., N.J.C.), Salt Lake City, UT, USAZvi Weizman - Gastroenterology Unit (Z.W.), Division of Pediatrics, Negev, IsraelNicola J Camp - Department of Medical Informatics (S.L.N., N.J.C.), Salt Lake City, UT, USAKhalil Elbedour - Genetic Institute (K.E., R.C.), Soroka University Medical Center, Ben-Gurion University of Negev, Negev, IsraelVal C Sheffield - Howard Hughes Medical Institute and Department of Pediatrics (V.C.S.), University of Iowa, Iowa City, IA, USAJohn J Zone - Department of Dermatology (J.J.Z.), University of Utah, Salt Lake City, UT, USARivka Carmi - Genetic Institute (K.E., R.C.), Soroka University Medical Center, Ben-Gurion University of Negev, Negev, Israel
- Resource Type
- Journal article
- Publication Details
- Human immunology, Vol.63(6), pp.502-507
- DOI
- 10.1016/S0198-8859(02)00395-6
- PMID
- 12039527
- NLM abbreviation
- Hum Immunol
- ISSN
- 0198-8859
- eISSN
- 1879-1166
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2002
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Medical Genetics and Genomics; Ophthalmology and Visual Sciences
- Record Identifier
- 9984065394302771
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