Journal article
HLA-DRA is associated with Parkinson's disease in Iranian population
International journal of immunogenetics, Vol.41(6), pp.508-511
12/01/2014
DOI: 10.1111/iji.12151
PMID: 25319953
Abstract
The rs3129882, a noncoding variant in HLA-DR, was found to be associated with Parkinson's disease (PD) using several genome-wide association studies. The aim of this replication study was to explore the relationship between this variant and PD in Iranian population. Genomic DNA was extracted from peripheral blood samples, and the rs3129882 SNP was genotyped using a PCR-RFLP method in 520 PD patients and 520 healthy Iranian controls. Significant differences were found in allele frequencies between patients and controls ((2)= 4.64, P=0.031). Under additive and dominant models, the association of the SNP with PD risk is significant, where the A allele was observed to be protective. The results suggest that rs3129882 polymorphism may be a risk factor for PD in Iranian. This is the first study reporting such an association in this population. More replication studies are needed to confirm this data.
Details
- Title: Subtitle
- HLA-DRA is associated with Parkinson's disease in Iranian population
- Creators
- J. Jamshidi - Fasa University of Medical SciencesA. Movafagh - Shahid Beheshti University of Medical SciencesB. Emamalizadeh - Shahid Beheshti University of Medical SciencesA. Zare Bidoki - Children's Medical CenterA. Manafi - Fasa University of Medical SciencesS. Ghasemi Firouzabadi - University of Social Welfare and Rehabilitation SciencesG-A. Shahidi - Iran University of Medical SciencesS. Kazeminasab - University of Social Welfare and Rehabilitation SciencesP. Petramfar - Shiraz University of Medical SciencesA. Fazeli - Shahid Beheshti University of Medical SciencesM. Motallebi - Shahid Beheshti University of Medical SciencesS. A. Mortazavi-Tabatabaei - Shahid Beheshti University of Medical SciencesA. Kowsari - Golestan UniversityZ. Jafarian - University of Social Welfare and Rehabilitation SciencesH. Darvish - Shahid Beheshti University of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- International journal of immunogenetics, Vol.41(6), pp.508-511
- DOI
- 10.1111/iji.12151
- PMID
- 25319953
- NLM abbreviation
- Int J Immunogenet
- ISSN
- 1744-3121
- eISSN
- 1744-313X
- Publisher
- Wiley
- Number of pages
- 4
- Grant note
- Fasa University of Medical Sciences
- Language
- English
- Date published
- 12/01/2014
- Academic Unit
- Neurology
- Record Identifier
- 9985014708902771
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