Journal article
HLA and Risk of Diffuse Large B cell Lymphoma After Solid Organ Transplantation
Transplantation, Vol.100(11), pp.2453-2460
11/2016
DOI: 10.1097/TP.0000000000001025
PMCID: PMC4893345
PMID: 26636741
Abstract
Solid organ transplant recipients have heightened risk for diffuse large B cell lymphoma (DLBCL). The role of donor-recipient HLA mismatch and recipient HLA type on DLBCL risk are not well established.
We examined 172 231 kidney, heart, pancreas, and lung recipients transplanted in the United States between 1987 and 2010, including 902 with DLBCL. Incidence rate ratios (IRRs) were calculated using Poisson regression for DLBCL risk in relation to HLA mismatch, types, and zygosity, adjusting for sex, age, race/ethnicity, year, organ, and transplant number.
Compared with recipients who had 2 HLA-DR mismatches, those with zero or 1 mismatch had reduced DLBCL risk, (zero: IRR, 0.76, 95% confidence interval [95% CI], 0.61-0.95; one: IRR, 0.83; 95% CI, 0.69-1.00). In stratified analyses, recipients matched at either HLA-A, -B, or -DR had a significantly reduced risk of late-onset (>2 years after transplantation), but not early-onset DLBCL, and there was a trend for decreasing risk with decreasing mismatch across all 3 loci (P = 0.0003). Several individual recipient HLA-A, -B, -C, -DR, and -DQ antigens were also associated with DLBCL risk, including DR13 (IRR, 0.74; 95% CI, 0.57-0.93) and B38 (IRR, 1.48; 95% CI, 1.10-1.93), confirming prior findings that these 2 antigens are associated with risk of infection-associated cancers.
In conclusion, variation in HLA is related to susceptibility to DLBCL, perhaps reflecting intensity of immunosuppression, control of Epstein-Barr virus infection among transplant recipients or chronic immune stimulation.
Details
- Title: Subtitle
- HLA and Risk of Diffuse Large B cell Lymphoma After Solid Organ Transplantation
- Creators
- Shehnaz K Hussain - 1 Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA. 2 Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA. 3 Terasaki Foundation Laboratory, Los Angeles, CA. 4 Departments of Obstetrics and Gynecology and Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA. 5 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD. 6 Cancer Prevention Institute of California, Fremont, CA. 7 Division of Epidemiology, Department of Health Research and Policy and Medicine, Stanford University School of Medicine, Stanford, CA. 8 Department of Epidemiology, University of Iowa, Iowa City, IA. 9 Scientific Registry of Transplant Recipients and Minneapolis Medical Research Foundation, Minneapolis, Minneapolis, MNSolomon B MakgoengMatthew J EverlyMarc T GoodmanOtoniel Martínez-MazaLindsay M MortonChristina A ClarkeCharles F LynchJon SnyderAjay IsraniBertram L KasiskeEric A Engels
- Resource Type
- Journal article
- Publication Details
- Transplantation, Vol.100(11), pp.2453-2460
- DOI
- 10.1097/TP.0000000000001025
- PMID
- 26636741
- PMCID
- PMC4893345
- NLM abbreviation
- Transplantation
- ISSN
- 0041-1337
- eISSN
- 1534-6080
- Publisher
- United States
- Grant note
- N01PC35142 / NCI NIH HHS HHSN261201000024C / NCI NIH HHS U58 DP000807 / NCCDPHP CDC HHS U58 DP000824 / NCCDPHP CDC HHS HHSN261201000036C / NCI NIH HHS U58 DP003875 / NCCDPHP CDC HHS U58 DP003931 / NCCDPHP CDC HHS N01PC35137 / NCI NIH HHS U58 DP003921 / NCCDPHP CDC HHS U58 DP000832 / NCCDPHP CDC HHS HHSN261201000035C / NCI NIH HHS U58 DP003879 / NCCDPHP CDC HHS HHSN261201300011C / CCR NIH HHS HHSN261201300071C / NCI NIH HHS U58 DP003920 / NCCDPHP CDC HHS U58 DP000848 / NCCDPHP CDC HHS HHSN261201000034C / NCI NIH HHS N01PC35139 / NCI NIH HHS P30 CA086862 / NCI NIH HHS HHSN261201300021C / NCI NIH HHS HHSN261201300011I / NCI NIH HHS HHSN261201000037C / NCI NIH HHS N01PC35143 / NCI NIH HHS K07 CA140360 / NCI NIH HHS U58 DP003883 / NCCDPHP CDC HHS HHSN261201000035I / NCI NIH HHS
- Language
- English
- Date published
- 11/2016
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995152502771
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