Journal article
HLA and environmental interactions in sarcoidosis
Sarcoidosis, vasculitis, and diffuse lung diseases, Vol.25(2), pp.125-132
12/01/2008
PMID: 19382531
Abstract
Sarcoidosis is a systemic granulomatosis of unknown etiology despite being described over 100 years ago. While both genetic predisposition and environmental exposures have been proposed as playing a role in this disease, there have not been any systematic investigations of gene-environmental interaction in this disease. In the ACCESS dataset, detailed environmental histories and high resolution HLA class II typing were performed on 476 cases of newly diagnosed sarcoidosis and 476 matched controls from the patients' community. We evaluated gene-environmental interactions in exposures or HLA class II alleles that were present in > 5% of the population and had an odd ratio of > 1.0. Four exposures and four HLA Class II alleles met these criteria and were evaluated. Significant interaction was observed between HLA DRB1*1101 and insecticide exposure at work (p < 0.10) and suggestive interaction was observed between HLA DRB1*1101 and exposure to mold and musty odors and DRB1*1501 and insecticide exposure at work (P < 0.15). In addition, HLA DRB1*1101 and insecticide exposure at work was associated with extrapulmonary sarcoidosis, specifically cardiac sarcoidosis and hypercalcemia (p<0.05) and HLA DRB1*1101 and exposure to molds and musty odors was associated with pulmonary only sarcoidosis (P < 0.05). These studies suggest that sarcoidosis is due to an interaction of genetic predisposition and environmental exposure in at least some cases of sarcoidosis. Future studies in defined phenotypes of sarcoidosis may be necessary to define environmental and genetic associations With sarcoidosis. (Sarcoidosis Vasc Diffuse Lung Dis 2008; 25: 125-132)
Details
- Title: Subtitle
- HLA and environmental interactions in sarcoidosis
- Creators
- M. D. Rossman - Hosp Univ Penn, Dept Med, Div Pulm Allergy & Crit Care, Philadelphia, PA 19104 USAR. Thompson - Clin Trials & Surveys Corp, Baltimore, MD USAM. Frederick - Clin Trials & Surveys Corp, Baltimore, MD USAM. C. Iannuzzi - Upstate Med Univ, Dept Internal Med, Syracuse, NY USAB. A. Ryhzcki - Henry Ford Hlth Sci Ctr, Div Biostat & Res Epidemiol, Detroit, MI USAJ. P. Pandey - Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USAL. S. Newman - University of DenverC. Rose - Natl Jewish Med & Res Ctr, Div Environm & Occupat Hlth Sci, Denver, CO USAE. Magira - Univ Penn, Dept Pediat, Philadelphia, PA 19104 USAD. Monos - Univ Penn, Dept Pediat, Philadelphia, PA 19104 USAA Case Control Etiology Study of Sarcoidosis (ACCESS) GroupLinda S Powers (Contributor) - Internal Medicine
- Resource Type
- Journal article
- Publication Details
- Sarcoidosis, vasculitis, and diffuse lung diseases, Vol.25(2), pp.125-132
- Publisher
- Mattioli 1885
- PMID
- 19382531
- ISSN
- 1124-0490
- eISSN
- 2532-179X
- Number of pages
- 8
- Grant note
- N01HR056073 / DIVISION OF LUNG DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) N01-HR-56071; N01-HR-56065; N01-HR-56072; N01-HR-56075; N01-HR-56073; N01-HR-56074; N01-HR-56070 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 12/01/2008
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984622750902771
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