Journal article
HOE-642 (cariporide) alters pHi and diastolic function after ischemia during reperfusion in pig hearts in situ
American journal of physiology. Heart and circulatory physiology, Vol.280(2), pp.H830-H834
02/01/2001
DOI: 10.1152/ajpheart.2001.280.2.H830
PMID: 11158983
Abstract
The specific Na+/H+ exchange inhibitor HOE-642 prevents ischemic and reperfusion injury in the myocardium. Although this inhibitor alters H+ ion flux during reperfusion in vitro, this action has not been confirmed during complex conditions in situ. Myocardial intracellular pH (pHi) and high-energy phosphates were monitored using 31P magnetic resonance spectroscopy in open-chest pigs supported by cardiopulmonary bypass during 10 min of ischemia and reperfusion. Intravenous HOE-642 (2 mg/kg; n = 8) administered before ischemia prevented the increases in diastolic stiffness noted in control pigs ( n = 8), although it did not alter the postischemic peak-elastance or pressure-rate product measured using a distensible balloon within the left ventricle. HOE-642 induced no change in pHi during ischemia but caused significant delays in intracellular realkalinization during reperfusion. HOE-642 did not alter phosphocreatine depletion and repletion but did improve ATP preservation. Na+/H+ exchange inhibition through HOE-642 delays intracellular alkalinization in the myocardium in situ during reperfusion in association with improved diastolic function and high-energy phosphate preservation.
Details
- Title: Subtitle
- HOE-642 (cariporide) alters pHi and diastolic function after ischemia during reperfusion in pig hearts in situ
- Creators
- Michael A Portman - Division of Cardiology, Department of Pediatrics, andAnthony L Panos - Division of Cardiothoracic Surgery, Department of Surgery, University of Washington and Children's Hospital and Regional Medical Center, Seattle, Washington 98105Yun Xiao - Division of Cardiology, Department of Pediatrics, andDavid L Anderson - Division of Cardiothoracic Surgery, Department of Surgery, University of Washington and Children's Hospital and Regional Medical Center, Seattle, Washington 98105Xue-Han Ning - Division of Cardiology, Department of Pediatrics, and
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.280(2), pp.H830-H834
- DOI
- 10.1152/ajpheart.2001.280.2.H830
- PMID
- 11158983
- NLM abbreviation
- Am J Physiol Heart Circ Physiol
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Language
- English
- Date published
- 02/01/2001
- Academic Unit
- Surgery; Cardiothoracic Surgery
- Record Identifier
- 9984051779802771
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