Journal article
HPA-axis abnormalities in psychiatrically well controls
Psychiatry research, Vol.20(4), pp.265-273
1987
DOI: 10.1016/0165-1781(87)90087-4
PMID: 3602213
Abstract
The considerable divergence in the literature describing dexamethasone suppression test (DST) nonsuppression rates among psychiatrically well controls led the authors to explore screening procedures as a possible source of variance. Using what they judged to be a typical screening procedure, the authors eliminated 69 of 128 subjects responding to an advertisement seeking psychiatrically and physically healthy subjects. Structured interviews for Axis I and II disorders then revealed that 36% of the remaining 59 subjects nevertheless had historical evidence of psychiatric illness; the 38 who passed all phases of screening underwent three monthly DSTs, which demonstrated the stability over time of both normal and abnormal results. Moreover, a family study revealed that relatives of nonsuppressors had a significantly higher morbid risk of affective disorder (20.5% vs. 8.8%), particularly mania and hypomania.
Details
- Title: Subtitle
- HPA-axis abnormalities in psychiatrically well controls
- Creators
- William Coryell - William Coryell, M.D., is Professor, University of Iowa College of Medicine, Department of Psychiatry, 500 Newton Rd., Iowa, City, IA 52242, USAMark Zimmerman - Mark Zimmerman, B.A., is Research Assistant, University of Iowa College of Medicine, Department of Psychiatry, 500 Newton Rd., Iowa, City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Psychiatry research, Vol.20(4), pp.265-273
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/0165-1781(87)90087-4
- PMID
- 3602213
- ISSN
- 0165-1781
- eISSN
- 1872-7123
- Language
- English
- Date published
- 1987
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003465202771
Metrics
30 Record Views