HPV prevalence and concordance in the cervix and oral cavity of pregnant women

E M Smith; J M Ritchie; J Yankowitz; D Wang; L P Turek; T H Haugen

doi:10.1080/10647440400009896

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HPV prevalence and concordance in the cervix and oral cavity of pregnant women

Journal article

Open access

Peer reviewed

HPV prevalence and concordance in the cervix and oral cavity of pregnant women

E M Smith, J M Ritchie, J Yankowitz, D Wang, L P Turek and T H Haugen

Infectious diseases in obstetrics and gynecology, Vol.12(2), pp.45-56

06/2004

DOI: 10.1080/10647440400009896

PMCID: PMC1784596

PMID: 15739817

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Abstract

This investigation examined human papillomavirus (HPV) in pregnant women in order to characterize viral prevalence, types and concordance between infection in the cervix and in the oral cavity. A total of 577 pregnant women seeking routine obstetric care were evaluated for HPV infection in their cervix during gestation and immediately before delivery, and in the oral cavity during gestation. Male partners present during the gestational clinic visit also provided a specimen from their oral cavity. HPV assessment was performed by PCR, dot blot hybridization and DNA sequencing. A sexual and health questionnaire was completed by the pregnant women. HPV prevalence in women was 29% in the cervix and 2.4% in the oral cavity. Among those with both gestational and delivery specimens, 35% were infected at least once and 20% had infection at both intervals. At delivery, 68% of infected women had an oncogenic HPV type in the cervix. There was no type-specific HPV concordance between the two cervical specimens, nor cervical and oral results in women, nor with cervical and oral findings between partners. The lack of association in HPV positivity and types between the cervix and oral cavity in these women suggests that self-inoculation is uncommon. This source of infection does not appear to be from oral contact with a current male partner, since there also was no concordance between partners. These results suggest either other modes of HPV transmission or differences in susceptibility to HPV infection or its clearance in the oral cavity and genital mucosa.

Pregnancy Complications, Infectious - virology

Cervix Uteri - virology

Humans

Papillomavirus Infections - epidemiology

DNA, Viral - analysis

Immunoblotting

Male

Vaginal Smears

Papillomaviridae - isolation & purification

Sequence Analysis, DNA

Papillomaviridae - genetics

Pregnancy

DNA, Viral - chemistry

Delivery, Obstetric

Mouth - virology

Papillomaviridae - classification

Polymerase Chain Reaction

Adult

Female

Surveys and Questionnaires

Sexual Partners

Papillomavirus Infections - transmission

Details

Title: Subtitle: HPV prevalence and concordance in the cervix and oral cavity of pregnant women
Creators: E M Smith - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA. elaine-smith@uiowa.edu
J M Ritchie
J Yankowitz
D Wang
L P Turek
T H Haugen
Resource Type: Journal article
Publication Details: Infectious diseases in obstetrics and gynecology, Vol.12(2), pp.45-56
DOI: 10.1080/10647440400009896
PMID: 15739817
PMCID: PMC1784596
NLM abbreviation: Infect Dis Obstet Gynecol
ISSN: 1064-7449
eISSN: 1098-0997
Publisher: Egypt
Grant note: R01 DE11979 / NIDCR NIH HHS
Language: English
Date published: 06/2004
Academic Unit: Epidemiology; Pathology; Obstetrics and Gynecology; Otolaryngology
Record Identifier: 9984047872502771

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