Journal article
HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic leukemia cells
Leukemia research, Vol.32(1), pp.143-149
01/01/2008
DOI: 10.1016/j.leukres.2007.05.009
PMID: 17617451
Abstract
The effects of a novel heat shock protein inhibitor, 17AAG, on established APL cell lines (NB4 and R1) were analyzed. 17AAG induces apoptosis in APL cell lines both sensitive (NB4) and resistant (R 1) to ATRA after 72 h of incubation. Apoptosis occurs by a mechanism different than ATRA-inediated response, as the cells do not undergo differentiation before apoptosis. Analysis of bax and bcl-2 shows that pro-apoptotic (bax) and anti-apoptotic (bcl-2) proteins are decreased in expression after incubation with 17AAG. We believe this data supports potential clinical use of agents that target HSP90 in APL patients failing conventional therapy. (c) 2007 Elsevier Ltd. All rights reserved.
Details
- Title: Subtitle
- HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic leukemia cells
- Creators
- Paul N. Meyer - Loyola University Medical CenterShantanu Roychowdhury - Loyola University Medical CenterAmeet R. Kini - Loyola University Medical CenterSerhan Alkan - Loyola University Medical Center
- Resource Type
- Journal article
- Publication Details
- Leukemia research, Vol.32(1), pp.143-149
- DOI
- 10.1016/j.leukres.2007.05.009
- PMID
- 17617451
- NLM abbreviation
- Leuk Res
- ISSN
- 0145-2126
- eISSN
- 1873-5835
- Publisher
- Elsevier
- Number of pages
- 7
- Language
- English
- Date published
- 01/01/2008
- Academic Unit
- Pathology
- Record Identifier
- 9984822991402771
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