HTR2A gene–child abuse interaction and association with a history of suicide attempt among Caucasian depressed psychiatric inpatients

Gen Shinozaki; Magdalena Romanowicz; David A Mrazek; Simon Kung

doi:10.1016/j.jad.2013.05.028

Back

HTR2A gene–child abuse interaction and association with a history of suicide attempt among Caucasian depressed psychiatric inpatients

Journal article

Peer reviewed

HTR2A gene–child abuse interaction and association with a history of suicide attempt among Caucasian depressed psychiatric inpatients

Gen Shinozaki, Magdalena Romanowicz, David A Mrazek and Simon Kung

Journal of affective disorders, Vol.150(3), pp.1200-1203

09/25/2013

DOI: 10.1016/j.jad.2013.05.028

PMID: 23759279

View Online

Abstract

The serotonin transporter gene polymorphism (5HTTLPR) has been associated with vulnerability for depression after exposure to stressful life event as well as with difference in treatment response to SSRI. Although the A/A genotype of the serotonin receptor SNP (rs7997012) was associated with better citalopram response than the G/G in the STAR⁎D sample, the effects of this SNP in the moderation of child abuse history on the characteristics of mental illnesses are not well understood. We examined if there are similar gene–environment interaction with the SNP. Retrospective chart review of 250 Caucasian depressed psychiatric inpatients, who had genotype for rs7997012. Subjects with each genotype were subcategorized into 2 groups with/without history of child abuse. The history of suicide attempts of each group was compared. A trend for an interaction was found between the HTR2A genotype and child abuse history influencing the prevalence of suicide attempts. Although each genotype did not show significant difference in the risk of suicide attempt when there was no abuse history, the A carriers (A/A+A/G) showed significantly higher rate of suicide attempt compared to the G/G when there is a history of child abuse (48.4% versus 22.7% respectively, p=0.0050). The likelihood ratio test from the logistic model showed a trend for an interaction between the A/A genotype and abuse history (Odds Ratio 2.10, χ2=2.49, p=0.11). Retrospective study design and small sample size with borderline significance. Our findings showed a potential interaction between the HTR2A gene and stressful life events.

Depression

Child abuse

Gene–environment interaction

HTR2A

Serotonin receptor 2A gene

Suicide attempt

Details

Title: Subtitle: HTR2A gene–child abuse interaction and association with a history of suicide attempt among Caucasian depressed psychiatric inpatients
Creators: Gen Shinozaki - Department of Psychiatry, University of South Dakota, Sioux Falls, SD, US
Magdalena Romanowicz - Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, US
David A Mrazek - Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, US
Simon Kung - Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, US
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.150(3), pp.1200-1203
DOI: 10.1016/j.jad.2013.05.028
PMID: 23759279
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier B.V
Language: English
Date published: 09/25/2013
Academic Unit: Psychiatry; Anesthesia; Neurosurgery
Record Identifier: 9984003407502771

Metrics

13 Record Views

14 Times Cited - Web of Science