Journal article
Habitual coffee consumption and subsequent risk of type 2 diabetes in individuals with a history of gestational diabetes - a prospective study
The American journal of clinical nutrition, Vol.116(6), pp.1693-1703
11/14/2022
DOI: 10.1093/ajcn/nqac241
PMCID: PMC9761754
PMID: 36373514
Abstract
Background Females with a history of gestational diabetes mellitus (GDM) are at higher risk of developing type 2 diabetes mellitus (T2D) later in life. Objective This study prospectively examined whether greater habitual coffee consumption was related to a lower risk of T2D among females with a history of GDM. Methods We followed 4522 participants with a history of GDM in the NHS II for incident T2D between 1991 and 2017. Demographic, lifestyle factors including diet, and disease outcomes were updated every 2-4 y. Participants reported consumption of caffeinated and decaffeinated coffee on validated FFQs. Fasting blood samples were collected in 2012-2014 from a subset of participants free of diabetes to measure glucose metabolism biomarkers (HbA1c, insulin, C-peptide; n = 518). We used multivariable Cox regression models to calculate adjusted HRs and 95% CIs for the risk of T2D. We estimated the least squares mean of glucose metabolic biomarkers according to coffee consumption. Results A total of 979 participants developed T2D. Caffeinated coffee consumption was inversely associated with the risk of T2D. Adjusted HR (95% CI) for <= 1 (nonzero), 2-3, and 4+ cups/d compared with 0 cup/d (reference) was 0.91 (0.78, 1.06), 0.83 (0.69, 1.01), and 0.46 (0.28, 0.76), respectively (P-trend = 0.004). Replacement of 1 serving/d of sugar-sweetened beverage and artificially sweetened beverage with 1 cup/d of caffeinated coffee was associated with a 17% (risk ratio [RR] = 0.83, 95% CI: 0.75, 0.93) and 9% (RR = 0.91, 95% CI: 0.84, 0.99) lower risk of T2D, respectively. Greater caffeinated coffee consumption was associated with lower fasting insulin and C-peptide concentrations (all P-trend <0.05). Decaffeinated coffee intake was not significantly related to T2D but was inversely associated with C-peptide concentrations (P-trend = 0.003). Conclusions Among predominantly Caucasian females with a history of GDM, greater consumption of caffeinated coffee was associated with a lower risk of T2D and a more favorable metabolic profile.
Details
- Title: Subtitle
- Habitual coffee consumption and subsequent risk of type 2 diabetes in individuals with a history of gestational diabetes - a prospective study
- Creators
- Jiaxi Yang - National University of SingaporeDeirdre K. Tobias - Harvard UniversityShanshan Li - Boston UniversityShilpa N. Bhupathiraju - Harvard UniversitySylvia H. Ley - Tulane UniversityStefanie N. Hinkle - University of PennsylvaniaFrank Qian - Harvard UniversityZhangling Chen - Erasmus MCYeyi Zhu - Kaiser PermanenteWei Bao - University of Science and Technology of ChinaJorge E. Chavarro - Harvard UniversityFrank B. Hu - Harvard UniversityCuilin Zhang - Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.116(6), pp.1693-1703
- Publisher
- Oxford Univ Press
- DOI
- 10.1093/ajcn/nqac241
- PMID
- 36373514
- PMCID
- PMC9761754
- ISSN
- 0002-9165
- eISSN
- 1938-3207
- Number of pages
- 11
- Grant note
- DOI: 10.13039/100000002, name: NIH, award: U01 CA176726, U01 HL145386, R01 CA67262, U01HL145386, P30 DK046200; DOI: 10.13039/100000041, name: American Diabetes Association; DOI: 10.13039/100000071, name: National Institute of Child Health and Human Development, award: HHSN275201000020C, HHSN275201100002I
- Language
- English
- Date published
- 11/14/2022
- Academic Unit
- Epidemiology
- Record Identifier
- 9984363562902771
Metrics
53 Record Views