Habitual pre-exercise caffeine supplementation prevents exercise-training induced attenuation of exercising systolic blood pressure and double-product

Kylee S West; Nate J Helwig; Laura E Schwager; Thomas W Hart; Anna C Zucker; Jacob S Venenga; Mark Flores; Nathaniel D M Jenkins

doi:10.1152/japplphysiol.00874.2024

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Habitual pre-exercise caffeine supplementation prevents exercise-training induced attenuation of exercising systolic blood pressure and double-product

Journal article

Peer reviewed

Habitual pre-exercise caffeine supplementation prevents exercise-training induced attenuation of exercising systolic blood pressure and double-product

Kylee S West, Nate J Helwig, Laura E Schwager, Thomas W Hart, Anna C Zucker, Jacob S Venenga, Mark Flores and Nathaniel D M Jenkins

Journal of applied physiology (1985), Vol.138(2), pp.358-365

02/01/2025

DOI: 10.1152/japplphysiol.00874.2024

PMCID: PMC12182273

PMID: 39726136

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Abstract

We examined the effect of habitual pre-exercise caffeine supplementation on training-induced adaptations to exercising systolic (SBP), diastolic (DBP), pulse pressure (PP), heart rate (HR), and double product (DP). Young women (mean±SD; 24±7 y) were randomized to a caffeine (120 mg) supplement (CAF; n=17) or placebo (PLA; n=16) group, completed 6-weeks of high intensity exercise training on three non-consecutive days per week, and supplemented with CAF or PLA 30-60 minutes before exercise or else upon waking. Before (PRE) and after (POST) the intervention, SBP, DBP, and HR were measured, and PP and DP calculated, at rest and during fixed-power exercise at 50W and 75W. Statistical analyses included three-way mixed factorial ANOVAs with post-hoc comparisons as necessary. Group×intensity×time interactions were observed for SBP ( =0.0105) and DP ( =0.003). SBP and DP increased with increasing exercise intensity at PRE and POST in both groups. However, whereas SBP and DP decreased PRE to POST at 50W and 75W in PLA, SBP and DP did not change at any intensity from PRE to POST in CAF. As intensity×time interaction was observed for DBP ( =0.006) indicating no change in resting DBP, but reductions from PRE to POST at 50W and 75W independent of group. Main effects of intensity ( <0.0001) and time ( =0.03) were observed for HR, and a main effect of intensity was observed for PP ( <0.0001). Habitual caffeine supplementation blunted training-induced reductions in exercising SBP and DP. Individuals may wish to avoid pre-exercise supplementation if seeking to maximize BP-lowering benefits of exercise.

exercise hypertension

cardiometabolic health

exercise pressor reflex

exercise training

Details

Title: Subtitle: Habitual pre-exercise caffeine supplementation prevents exercise-training induced attenuation of exercising systolic blood pressure and double-product
Creators: Kylee S West - University of Iowa
Nate J Helwig - University of Iowa
Laura E Schwager - University of Iowa
Thomas W Hart - University of Iowa
Anna C Zucker - University of Iowa
Jacob S Venenga - University of Iowa
Mark Flores - University of Iowa
Nathaniel D M Jenkins - University of Iowa
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.138(2), pp.358-365
DOI: 10.1152/japplphysiol.00874.2024
PMID: 39726136
PMCID: PMC12182273
NLM abbreviation: J Appl Physiol (1985)
ISSN: 1522-1601
eISSN: 1522-1601
Publisher: AMER PHYSIOLOGICAL SOC
Grant note: Applied Food Sciences, Inc UL1TR002537 / HHS | NIH | National Center for Advancing Translational Sciences (NCATS)
Language: English
Electronic publication date: 12/26/2024
Date published: 02/01/2025
Academic Unit: Center for Social Science Innovation; Injury Prevention Research Center; Health, Sport, and Human Physiology
Record Identifier: 9984769622302771

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