Journal article
Haematogones in the peripheral blood of adults: a four-colour flow cytometry study of 102 patients
British journal of haematology, Vol.126(2), pp.209-212
2004
DOI: 10.1111/j.1365-2141.2004.05011.x
PMID: 15238141
Abstract
Haematogones have been extensively characterized in bone marrow, but not in the peripheral blood (PB). We studied 102 PB samples from adult patients with a sensitive flow cytometry method. Sixty-six of 102 samples (65%) contained detectable haematogones, ranging from 0.01% to 1.3% of white blood cells (median 0.06%, mean 0.13%). Of 66 cases with complete blood count data, 51 had absolute haematogone counts of 0.00037-0.105 x 10(9)/l (median 0.0054 x 10(9)/l, mean 0.012 x 10(9)/l). PB haematogones belonged exclusively to the most mature maturational stage. These findings have implications for PB analysis of minimal residual disease in acute lymphoblastic leukaemia and follicular lymphoma.
Details
- Title: Subtitle
- Haematogones in the peripheral blood of adults: a four-colour flow cytometry study of 102 patients
- Creators
- Steven H KROFT - University of Texas Southwestern Medical Center, Dallas, TX, United StatesSheryl L ASPLUND - University of Texas Southwestern Medical Center, Dallas, TX, United StatesRobert W MCKENNA - University of Texas Southwestern Medical Center, Dallas, TX, United StatesNitin J KARANDIKAR - University of Texas Southwestern Medical Center, Dallas, TX, United States
- Resource Type
- Journal article
- Publication Details
- British journal of haematology, Vol.126(2), pp.209-212
- Publisher
- Blackwell; Oxford
- DOI
- 10.1111/j.1365-2141.2004.05011.x
- PMID
- 15238141
- ISSN
- 0007-1048
- eISSN
- 1365-2141
- Language
- English
- Date published
- 2004
- Academic Unit
- Pathology
- Record Identifier
- 9984047895002771
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