Journal article
Haemostatic efficacy of single‐dose factor administration in neonates with severe haemophilia undergoing circumcision
Haemophilia : the official journal of the World Federation of Hemophilia, Vol.26(5), pp.786-792
08/03/2020
DOI: 10.1111/hae.14122
PMID: 32746496
Abstract
Introduction
Perioperative management of children with haemophilia undergoing surgery is a complex and understudied topic. Circumcision is the most common procedure performed in the neonatal period, and guidelines to prevent bleeding complications from circumcision are lacking. Treatment protocols vary widely, and many centres treat patients with factor products for up to two weeks after circumcision. There is an unmet need for studies evaluating optimal factor replacement therapy around the time of circumcision in neonates with severe haemophilia.
Aim
To determine the efficacy of a single dose of factor replacement before circumcision to prevent bleeding complications in neonates with severe haemophilia.
Methods
We conducted a retrospective chart review of male infants born between January 2000 and June 2019. Male neonates with severe haemophilia diagnosed at the Iowa Hemophilia and Thrombosis Center (n = 22) and healthy newborn controls who underwent circumcision at the University of Iowa Hospitals were included. Data were collected from the electronic medical record. Neonates with severe haemophilia were separated into two groups—those pretreated with one dose of factor replacement before circumcision and those without pretreatment.
Results
We observed that neonates with severe haemophilia pretreated with a single dose of factor VIII or factor IX replacement had significantly reduced bleeding complications, shorter hospital stay and required less therapeutic intervention compared with untreated patients. Importantly, pretreated patients had outcomes similar to healthy controls.
Conclusions
Our results demonstrate that a single dose of factor replacement before circumcision is effective to prevent bleeding in neonates with severe haemophilia.
Details
- Title: Subtitle
- Haemostatic efficacy of single‐dose factor administration in neonates with severe haemophilia undergoing circumcision
- Creators
- Neeraja Swaminathan - Stead Family Department of Pediatrics University of Iowa Iowa City IA USACollin Thatcher - Carver College of Medicine University of Iowa Iowa City IA USAJanice M Staber - Stead Family Department of Pediatrics University of Iowa Iowa City IA USA, Carver College of Medicine University of Iowa Iowa City IA USA
- Resource Type
- Journal article
- Publication Details
- Haemophilia : the official journal of the World Federation of Hemophilia, Vol.26(5), pp.786-792
- DOI
- 10.1111/hae.14122
- PMID
- 32746496
- ISSN
- 1351-8216
- eISSN
- 1365-2516
- Language
- English
- Date published
- 08/03/2020
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Hematology/Oncology
- Record Identifier
- 9984070897202771
Metrics
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