Hallucinations, neuroplasticity, and prediction errors in schizophrenia

Amanda McCleery; Jonathan K Wynn; Daniel H Mathalon; Brian J Roach; Michael F Green

doi:10.1111/sjop.12413

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Hallucinations, neuroplasticity, and prediction errors in schizophrenia

Journal article

Open access

Peer reviewed

Hallucinations, neuroplasticity, and prediction errors in schizophrenia

Amanda McCleery, Jonathan K Wynn, Daniel H Mathalon, Brian J Roach and Michael F Green

Scandinavian journal of psychology, Vol.59(1), pp.41-48

02/2018

DOI: 10.1111/sjop.12413

PMCID: PMC5969574

PMID: 29356009

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https://www.ncbi.nlm.nih.gov/pmc/articles/5969574View

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Abstract

Auditory hallucinations, a hallmark symptom of psychosis, are experienced by most people with a diagnosis of schizophrenia at some point in their illness. Auditory hallucinations can be understood as a failure in predictive coding, whereby abnormalities in sensory/perceptual processing combine with biased cognitive processes to result in a dampening of normal prediction error signaling. In this paper, we used a roving mismatch negativity (MMN) paradigm to optimize evaluation of prediction error signaling and short-term neuroplasticity in 30 people with schizophrenia (n = 16 with and n = 14 without recent auditory hallucinations) and 20 healthy comparison participants. The recent hallucinations group exhibited an abnormal roving MMN profile [F(2,27) = 3.98, p = 0.03], significantly reduced prediction error signaling [t(28) = -2.25, p = 0.03], and a trend for diminished short-term neuroplasticity [t(28) = 1.80, p = 0.08]. There were no statistically significant differences between the healthy comparison group and the combined schizophrenia group on any of the roving MMN indices. These findings are consistent with a predictive coding account of hallucinations in schizophrenia, which posits reduced prediction error signaling in those who are prone to hallucinations. These results also suggest that plasticity-mediated formation and online updating of predictive coding models may also be disrupted in individuals with recent hallucinations.

Acoustic Stimulation

Brain - physiopathology

Humans

Middle Aged

Male

Electroencephalography

Schizophrenic Psychology

Neuropsychological Tests

Neuronal Plasticity

Schizophrenia - physiopathology

Hallucinations

Adult

Female

Details

Title: Subtitle: Hallucinations, neuroplasticity, and prediction errors in schizophrenia
Creators: Amanda McCleery - Veterans Affairs Greater Los Angeles, Veterans Integrated Service Network 22 Mental Illness Research, Education, and Clinical Center, Los Angeles, CA, USA
Jonathan K Wynn - Veterans Affairs Greater Los Angeles, Veterans Integrated Service Network 22 Mental Illness Research, Education, and Clinical Center, Los Angeles, CA, USA
Daniel H Mathalon
Brian J Roach
Michael F Green - Veterans Affairs Greater Los Angeles, Veterans Integrated Service Network 22 Mental Illness Research, Education, and Clinical Center, Los Angeles, CA, USA
Resource Type: Journal article
Publication Details: Scandinavian journal of psychology, Vol.59(1), pp.41-48
DOI: 10.1111/sjop.12413
PMID: 29356009
PMCID: PMC5969574
NLM abbreviation: Scand J Psychol
ISSN: 0036-5564
eISSN: 1467-9450
Publisher: England
Grant note: T32 MH096682 / NIMH NIH HHS K23 MH108829 / NIMH NIH HHS
Language: English
Date published: 02/2018
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065367102771

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