Journal article
Haloperidol Plasma Levels and Acute Clinical Change in Schizophrenia
Journal of clinical psychopharmacology, Vol.10(6), pp.397-402
12/1990
DOI: 10.1097/00004714-199010060-00003
PMID: 2286709
Abstract
Twenty-five inpatients with acute exacerbations of schizophrenia (by Research Diagnostic Criteria) or schizoaffective disorder underwent a prospective haloperidol dosing procedure and were assigned fixed doses chosen to yield a distribution of haloperidol plasma levels above and below a hypothesized upper therapeutic limit of 18 ng/ml. Changes in Brief Psychiatric Rating Scale scores after 1 week of treatment were negatively correlated with haloperidol plasma levels, and the statistically optimum cutoff point fell near the predicted 18 ng/ml. Plasma level/response relationships over the subsequent 3 weeks were weaker but patients with higher plasma levels had consistently less improvement.
Details
- Title: Subtitle
- Haloperidol Plasma Levels and Acute Clinical Change in Schizophrenia
- Creators
- WILLIAM CORYELLMICHAEL KELLYPAUL J PERRYDEL D MILLER
- Resource Type
- Journal article
- Publication Details
- Journal of clinical psychopharmacology, Vol.10(6), pp.397-402
- DOI
- 10.1097/00004714-199010060-00003
- PMID
- 2286709
- ISSN
- 0271-0749
- eISSN
- 1533-712X
- Language
- English
- Date published
- 12/1990
- Academic Unit
- Pharmacy; Psychiatry; Pharmacy Practice and Science
- Record Identifier
- 9984003481302771
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