Hard and soft micro- and nanofabrication: An integrated approach to hydrogel-based biosensing and drug delivery

Ronald A Siegel; Yuandong Gu; Ming Lei; Antonio Baldi; Eric E Nuxoll; Babak Ziaie

doi:10.1016/j.jconrel.2009.12.012

Back

Hard and soft micro- and nanofabrication: An integrated approach to hydrogel-based biosensing and drug delivery

Journal article

Peer reviewed

Hard and soft micro- and nanofabrication: An integrated approach to hydrogel-based biosensing and drug delivery

Ronald A Siegel, Yuandong Gu, Ming Lei, Antonio Baldi, Eric E Nuxoll and Babak Ziaie

Journal of controlled release, Vol.141(3), pp.303-313

2010

DOI: 10.1016/j.jconrel.2009.12.012

PMCID: PMC2846451

PMID: 20036310

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/2846451View

Open Access

Abstract

We review efforts to produce microfabricated glucose sensors and closed-loop insulin delivery systems. These devices function due to the swelling and shrinking of glucose-sensitive microgels that are incorporated into silicon-based microdevices. The glucose response of the hydrogel is due to incorporated phenylboronic acid (PBA) side chains. It is shown that in the presence of glucose, these polymers alter their swelling properties, either by ionization or by formation of glucose-mediated reversible crosslinks. Swelling pressures impinge on microdevice structures, leading either to a change in resonant frequency of a microcircuit, or valving action. Potential areas for future development and improvement are described. Finally, an asymmetric nano-microporous membrane, which may be integrated with the glucose-sensitive devices, is described. This membrane, formed using photolithography and block polymer assembly techniques, can be functionalized to enhance its biocompatibility and solute size selectivity. The work described here features the interplay of design considerations at the supramolecular, nano, and micro scales.

Block polymers

Closed-loop insulin delivery

Glucose sensing

Hydrogels

Microfabrication

Microporous membrane

Nanoporous membrane

Self-assembly

Swelling

Details

Title: Subtitle: Hard and soft micro- and nanofabrication: An integrated approach to hydrogel-based biosensing and drug delivery
Creators: Ronald A Siegel - University of Minnesota
Yuandong Gu - University of Minnesota
Ming Lei - University of Minnesota
Antonio Baldi - University of Minnesota
Eric E Nuxoll - University of Minnesota
Babak Ziaie - University of Minnesota
Resource Type: Journal article
Publication Details: Journal of controlled release, Vol.141(3), pp.303-313
DOI: 10.1016/j.jconrel.2009.12.012
PMID: 20036310
PMCID: PMC2846451
NLM abbreviation: J Control Release
ISSN: 0168-3659
eISSN: 1873-4995
Publisher: Elsevier B.V
Grant note: DOI: 10.13039/501100003176, name: Ministerio de Educación, Cultura y Deporte; DOI: 10.13039/100000001, name: National Science Foundation, award: DMR-0605880; DOI: 10.13039/100000002, name: National Institutes of Health, award: DK075739, EB003125, HD040366, HD051366; DOI: 10.13039/100006751, name: U.S. Army, award: DA/DAMD17-02-1-0722; DOI: 10.13039/100013111, name: Materials Research Science and Engineering Center, Harvard University; DOI: 10.13039/501100000781, name: European Research Council
Language: English
Date published: 2010
Academic Unit: Pharmaceutical Sciences and Experimental Therapeutics; Chemical and Biochemical Engineering
Record Identifier: 9984197087402771

Metrics

30 Record Views

86 Times Cited - Web of Science