Journal article
Head and neck cancer associated with herpes simplex virus 1 and 2 and other risk factors
Oral oncology, Vol.42(3), pp.288-296
2006
DOI: 10.1016/j.oraloncology.2005.08.003
PMID: 16324878
Abstract
We investigated whether herpes simplex viruses, HSV-1 and HSV-2, are cofactors of head and neck cancer (HNC) in association with tobacco, alcohol, or HPV-16 infection. The study included 164 HNC cases and 295 controls. Serologic tests were used to distinguish HSV-1 and HSV-2. Antibodies to anti-VLP HPV-16 and HPV-16 E6 and E7 were evaluated by ELISA. After adjusting for age, tobacco, alcohol use, and number of sexual partners, risk of cancer was not significantly increased in those with HSV-1 [adjusted odds ratio (OR)
=
0.7] or HSV-2 (OR
=
0.8) compared to HSV-negative patients. Although heavy use of tobacco, alcohol and HPV-16 infection was associated with an increased risk of HNC, the adjusted risk among those infected with HSV-1 or HSV-2 lowered the odds compared to those who were not infected. Heavy smokers (OR
=
1.7) and heavy drinkers infected with HSV-1 (OR
=
4.2) or HSV-2 (smokers: OR
=
1.6; drinkers: OR
=
3.2) had lower odds compared to seronegative HSV-1 heavy users (smokers: OR
=
2.5; drinkers: OR
=
5.5) or HSV-2 (smokers: OR
=
1.9; drinkers: OR
=
6.2). Those seropositive to HPV-16 E6 and/or E7 but not HSV-1 (OR
=
27.4) or HSV-2 (OR
=
18.0) had higher risk of HNC compared to those infected with HSV-1 (OR
=
16.7) or HSV-2 (not estimable). These findings suggest that seropositivity to HSV-1 and HSV-2, although not independent risk factors for HNC, may modify the risk of HNC associated with exposure to tobacco, alcohol, or HPV-HR.
Details
- Title: Subtitle
- Head and neck cancer associated with herpes simplex virus 1 and 2 and other risk factors
- Creators
- Tina M Parker - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USAElaine M Smith - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USAJustine M Ritchie - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USAThomas H Haugen - Veterans Affairs Medical Center and Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, USAVladimir Vonka - Institute of Hematology and Blood Transfusion, Prague, Czech RepublicLubomir P Turek - Veterans Affairs Medical Center and Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, USAEva Hamsikova - Institute of Hematology and Blood Transfusion, Prague, Czech Republic
- Resource Type
- Journal article
- Publication Details
- Oral oncology, Vol.42(3), pp.288-296
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.oraloncology.2005.08.003
- PMID
- 16324878
- ISSN
- 1368-8375
- eISSN
- 1879-0593
- Language
- English
- Date published
- 2006
- Academic Unit
- Epidemiology; Pathology
- Record Identifier
- 9984047693802771
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