Head-repositioning does not reduce the reproducibility of fMRI activation in a block-design motor task

David A. Soltysik; David Thomasson; Sunder Rajan; Javier Gonzalez-Castillo; Paul DiCamillo; Nadia Biassou

doi:10.1016/j.neuroimage.2011.03.023

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Head-repositioning does not reduce the reproducibility of fMRI activation in a block-design motor task

Journal article

Peer reviewed

Head-repositioning does not reduce the reproducibility of fMRI activation in a block-design motor task

David A. Soltysik, David Thomasson, Sunder Rajan, Javier Gonzalez-Castillo, Paul DiCamillo and Nadia Biassou

NeuroImage (Orlando, Fla.), Vol.56(3), pp.1329-1337

06/01/2011

DOI: 10.1016/j.neuroimage.2011.03.023

PMCID: PMC3085718

PMID: 21406235

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Abstract

It is hypothesized that, based upon partial volume effects and spatial non-uniformities of the scanning environment, repositioning a subject's head inside the head coil between separate functional MRI scans will reduce the reproducibility of fMRI activation compared to a series of functional runs where the subject's head remains in the same position. Nine subjects underwent fMRI scanning where they performed a sequential, oppositional finger-tapping task. The first five runs were conducted with the subject's head remaining stable inside the head coil. Following this, four more runs were collected after the subject removed and replaced his/her head inside the head coil before each run. The coefficient of variation was calculated for four metrics: the distance from the anterior commisure to the center of mass of sensorimotor activation, maximum t-statistic, activation volume, and average percent signal change. These values were compared for five head-stabilization runs and five head-repositioning runs. Voxelwise intraclass correlation coefficients were also calculated to assess the spatial distribution of sources of variance. Interestingly, head repositioning was not seen to significantly affect the reproducibility of fMRI activation (p<0.05). In addition, the threshold level affected the reproducibility of activation volume and percent signal change. ► Head repositioning did not reduce the reproducibility of fMRI activation. ► Location of activation was highly reproducible across intrasession runs. ► Increasing threshold lowered the reproducibility of activation volume. ► Increasing threshold increased the reproducibility of average percent signal change.

Finger-tapping

fMRI

Reproducibility

Test–retest

Details

Title: Subtitle: Head-repositioning does not reduce the reproducibility of fMRI activation in a block-design motor task
Creators: David A. Soltysik - Center for Devices and Radiological Health
David Thomasson - Department of Radiology, National Institutes of Health, Bethesda, MD, 20892, USA
Sunder Rajan - Center for Devices and Radiological Health
Javier Gonzalez-Castillo - Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
Paul DiCamillo - National Institutes of Health
Nadia Biassou - Department of Radiology, National Institutes of Health, Bethesda, MD, 20892, USA
Resource Type: Journal article
Publication Details: NeuroImage (Orlando, Fla.), Vol.56(3), pp.1329-1337
DOI: 10.1016/j.neuroimage.2011.03.023
PMID: 21406235
PMCID: PMC3085718
NLM abbreviation: Neuroimage
ISSN: 1053-8119
eISSN: 1095-9572
Publisher: Elsevier Inc
Grant note: name: Radiology and Imaging Sciences Department of the Warren G. Magnuson Clinical Center at the National Institutes of Health
Language: English
Date published: 06/01/2011
Academic Unit: Radiology
Record Identifier: 9984318711902771

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