Journal article
Health-Related Quality of Life in Pediatric Acute Recurrent or Chronic Pancreatitis: Association With Biopsychosocial Risk Factors
Journal of pediatric gastroenterology and nutrition, Vol.74(5), pp.636-642
05/01/2022
DOI: 10.1097/MPG.0000000000003420
PMCID: PMC9117452
PMID: 35192575
Abstract
Abdominal pain, emergency department visits, and hospitalizations impact lives of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Data on health-related quality of life (HRQOL) in this population, however, remains limited. We aimed to evaluate HRQOL in children with ARP or CP; and test biopsychosocial risk factors associated with low HRQOL.
Data were acquired from the INternational Study Group of Pediatric Pancreatitis: In search for a cuRE registry. Baseline demographic and clinical questionnaires, the Child Health Questionnaire (measures HRQOL) and Child Behavior Checklist (measures emotional and behavioral functioning) were completed at enrollment.
The sample included 368 children (54.3% girls, mean age = 12.7years, standard deviation [SD] = 3.3); 65.2% had ARP and 34.8% with CP. Low physical HRQOL (M = 38.5, SD = 16.0) was demonstrated while psychosocial HRQOL (M = 49.5, SD = 10.2) was in the normative range. Multivariate regression analysis revealed that clinical levels of emotional and behavioral problems (B = -10.28, P < 0.001), episodic and constant abdominal pain (B = 04.66, P = 0.03; B = -13.25, P < 0.001) were associated with low physical HRQOL, after accounting for ARP/CP status, age, sex, exocrine, and endocrine disease (F [9, 271] = 8.34, P < 0.001). Borderline and clinical levels of emotional and behavioral problems (B = -10.18, P < 0.001; B = -15.98, P < 0.001), and constant pain (B = -4.46, P < 0.001) were associated with low psychosocial HRQOL (F [9, 271] = 17.18, P < 0.001).
Findings highlight the importance of assessing HRQOL and treating pain and psychosocial problems in this vulnerable group of children.
Details
- Title: Subtitle
- Health-Related Quality of Life in Pediatric Acute Recurrent or Chronic Pancreatitis: Association With Biopsychosocial Risk Factors
- Creators
- See Wan Tham - Department of Anesthesiology & Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA The University of Texas, MD Anderson Cancer Center, Houston, TX Nationwide Children's Hospital, Columbus, OH, USA University of Iowa, Stead Family Children's Hospital, Iowa City, IA; USA Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, Cincinnati, OH, USA University of Minnesota Masonic Children's Hospital, Minneapolis, Minnesota, USA UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA Division of Pediatric Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine and Texas Children's Hospital; Houston, TX, USA Hospital for Sick Children, Toronto, ON, Canada University of California San Francisco, San Francisco, CA, USA Children's Hospital of Philadelphia, Philadelphia, PA, USA Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA Montreal Children's Hospital, McGill University, Montreal, QC, Canada School of Women's and Children's Health, Faculty of Medicine, University of New South Wales and Department of Gastroenterology, Sydney Children's Hospital Randwick, Sydney, NSW, Australia Stanford University, Stanford Children's Health, Palo Alto, CA, USA Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA University of Texas Southwestern Medical School, Dallas, TX, USA Hadassah Hebrew University Hospital, Jerusalem, Israel Children's Hospital Los Angeles, Los Angeles, CA Washington University School of Medicine, St. Louis, MO, USA.Fuchenchu Wang - The University of Texas, MD Anderson Cancer Center, Houston, TXCheryl E Gariepy - Nationwide Children's HospitalGretchen A Cress - University of IowaMaisam A Abu-El-Haija - University of CincinnatiMelena D Bellin - University of MinnesotaKate M Ellery - UPMC Children's Hospital of Pittsburgh, Pittsburgh, PADouglas S Fishman - Baylor College of MedicineTanja Gonska - Hospital for Sick ChildrenMelvin B Heyman - University of California, San FranciscoTom K Lin - University of CincinnatiAsim Maqbool - Children's Hospital of PhiladelphiaBrian A McFerron - Indiana UniversityVeronique D Morinville - Montreal Children's Hospital, McGill University, Montreal, QCJaimie D Nathan - Nationwide Children's HospitalChee Y Ooi - UNSW SydneyEmily R Perito - University of California, San FranciscoSarah Jane Schwarzenberg - University of MinnesotaZachary M Sellers - Stanford University, Stanford Children's Health, Palo Alto, CAUzma Shah - Harvard Medical SchoolDavid M Troendle - University of Texas Southwestern Medical School, Dallas, TXMichael Wilschanski - Hadassah Hebrew University Hospital, Jerusalem, IsraelYuhua Zheng - Children's Hospital Los Angeles, Los Angeles, CAYing Yuan - The University of Texas MD Anderson Cancer CenterMark E Lowe - Washington University School of Medicine, St. Louis, MOAliye Uc - University of IowaTonya M Palermo - Department of Anesthesiology & Pain Medicine, University of Washington School of Medicine, Seattle, WAINternational Study Group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE) and Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC)
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric gastroenterology and nutrition, Vol.74(5), pp.636-642
- DOI
- 10.1097/MPG.0000000000003420
- PMID
- 35192575
- PMCID
- PMC9117452
- NLM abbreviation
- J Pediatr Gastroenterol Nutr
- ISSN
- 0277-2116
- eISSN
- 1536-4801
- Grant note
- K23 DK118111 / NIDDK NIH HHS U01 DK108334 / NIDDK NIH HHS U01 DK108328 / NIDDK NIH HHS
- Language
- English
- Date published
- 05/01/2022
- Academic Unit
- Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984313088202771
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