Journal article
Health-related quality of life in glomerular disease
Kidney international, Vol.95(5), pp.1209-1224
05/2019
DOI: 10.1016/j.kint.2018.12.018
PMCID: PMC6743723
PMID: 30898342
Abstract
There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). We assessed the relationship between HRQOL and demographic and clinical variables in 478 children and 1115 adults at the time of enrollment into CureGN. Domains measured by PROMIS items included global assessments of health, mobility, anxiety, fatigue, and sleep impairment, as well as a derived composite measure incorporating all measured domains. Multivariable models were created that explained 7 to 32% of variance in HRQOL. Patient-reported edema consistently had the strongest and most robust association with each measured domain of HRQOL in multivariable analysis (adjusted β [95% CI] for composite PROMIS score in children, -5.2 [-7.1 to -3.4]; for composite PROMIS score in adults, -6.1 [-7.4 to -4.9]). Female sex, weight (particularly obesity), and estimated glomerular filtration rate were also associated with some, but not all, domains of HRQOL. Primary diagnosis, disease duration, and exposure to immunosuppression were not associated with HRQOL after adjustment. Sensitivity analyses and interaction testing demonstrated no significant association between disease duration or immunosuppression and any measured domain of HRQOL. Thus, patient-reported edema has a consistent negative association with HRQOL in patients with primary glomerular diseases, with substantially greater impact than other demographic and clinical variables.
Details
- Title: Subtitle
- Health-related quality of life in glomerular disease
- Creators
- Pietro A Canetta - Columbia UniversityJonathan P Troost - University of MichiganShannon Mahoney - University of North Carolina at Chapel HillAmy J Kogon - Boston Children's HospitalNoelle Carlozzi - University of MichiganSharon M Bartosh - University of Wisconsin–MadisonYi Cai - Boston Children's HospitalT Keefe Davis - Washington University in St. LouisHilda Fernandez - Columbia UniversityAlessia Fornoni - University of MiamiRasheed A Gbadegesin - Duke UniversityEmily Herreshoff - University of MichiganJohn D Mahan - Nationwide Children's HospitalPatrick H Nachman - University of North Carolina at Chapel HillDavid T Selewski - University of MichiganChristine B Sethna - Cohen Children's Medical CenterTarak Srivastava - University of Missouri–Kansas CityKatherine R Tuttle - University of WashingtonChia-Shi Wang - Emory University School of MedicineRonald J Falk - University of North Carolina at Chapel HillAli G Gharavi - Columbia UniversityBrenda W Gillespie - University of MichiganLarry A Greenbaum - Emory UniversityLawrence B Holzman - University of PennsylvaniaMatthias Kretzler - University of MichiganBruce M Robinson - University of MichiganWilliam E Smoyer - The Ohio State UniversityLisa M Guay-Woodford - Deparment of Nephrology, Center for Translational Science, Children's National Health System, Washington, District of Columbia, USABryce Reeve - Duke UniversityDebbie S Gipson - University of MichiganCureGN Consortium
- Contributors
- Carla Nester (Contributor) - University of Iowa, Nephrology, Dialysis and Transplantation
- Resource Type
- Journal article
- Publication Details
- Kidney international, Vol.95(5), pp.1209-1224
- DOI
- 10.1016/j.kint.2018.12.018
- PMID
- 30898342
- PMCID
- PMC6743723
- NLM abbreviation
- Kidney Int
- ISSN
- 0085-2538
- eISSN
- 1523-1755
- Grant note
- UM1 DK100867 / NIDDK NIH HHS UM1 DK100845 / NIDDK NIH HHS UL1 TR002548 / NCATS NIH HHS UM1 DK100866 / NIDDK NIH HHS UM1 DK100876 / NIDDK NIH HHS U01 DK100846 / NIDDK NIH HHS UM1 DK100846 / NIDDK NIH HHS
- Language
- English
- Date published
- 05/2019
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984353889102771
Metrics
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