Healthy lifestyles related to subsequent prevalence of age-related macular degeneration

Julie A Mares; Rick P Voland; Sherie A Sondel; Amy E Millen; Tara Larowe; Suzen M Moeller; Mike L Klein; Barbara A Blodi; Richard J Chappell; Lesley Tinker; Cheryl Ritenbaugh; Karen M Gehrs; Gloria E Sarto; Elizabeth Johnson; D Max Snodderly; Robert B Wallace

doi:10.1001/archophthalmol.2010.314

Back

Healthy lifestyles related to subsequent prevalence of age-related macular degeneration

Journal article

Open access

Peer reviewed

Healthy lifestyles related to subsequent prevalence of age-related macular degeneration

Julie A Mares, Rick P Voland, Sherie A Sondel, Amy E Millen, Tara Larowe, Suzen M Moeller, Mike L Klein, Barbara A Blodi, Richard J Chappell, Lesley Tinker, …

Archives of ophthalmology (1960), Vol.129(4), pp.470-480

04/2011

DOI: 10.1001/archophthalmol.2010.314

PMCID: PMC3075357

PMID: 21149749

Files and links (1)

url

https://doi.org/10.1001/archophthalmol.2010.314View

Published (Version of record) Open Access

Abstract

To investigate the relationships between lifestyle behaviors of diet, smoking, and physical activity and the subsequent prevalence of age-related macular degeneration (AMD). The population included 1313 participants (aged 55-74 years) in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative Observational Study. Scores on a modified 2005 Healthy Eating Index were assigned using responses to a food frequency questionnaire administered at baseline of the Women's Health Initiative Observational Study (1994-1998). Physical activity and lifetime smoking history were queried. An average of 6 years later, stereoscopic fundus photographs were taken to assess the presence and severity of AMD; it was present in 202 women, 94% of whom had early AMD, the primary outcome. In multivariate models, women whose diets scored in the highest quintile compared with the lowest quintile on the modified 2005 Healthy Eating Index had 46% lower odds for early AMD. Women in the highest quintile compared with those in the lowest quintile for physical activity (in metabolic energy task hours per week) had 54% lower odds for early AMD. Although smoking was not independently associated with AMD on its own, having a combination of 3 healthy behaviors (healthy diet, physical activity, and not smoking) was associated with 71% lower odds for AMD compared with having high-risk scores (P < .001). Modifying lifestyles might reduce risk for early AMD as much as 3-fold, lowering the risk for advanced AMD in a person's lifetime and the social and economic costs of AMD to society.

Health Behavior

United States - epidemiology

Life Style

Prevalence

Tocopherols - blood

Humans

Middle Aged

Chromatography, High Pressure Liquid

Zeaxanthins

Macular Degeneration - diagnosis

C-Reactive Protein - metabolism

Lutein - administration & dosage

Macular Degeneration - epidemiology

Female

Surveys and Questionnaires

Xanthophylls - administration & dosage

Tocopherols - administration & dosage

Risk Factors

Feeding Behavior

Lutein - blood

Macular Degeneration - blood

Xanthophylls - blood

Diet

Aged

Exercise - physiology

Details

Title: Subtitle: Healthy lifestyles related to subsequent prevalence of age-related macular degeneration
Creators: Julie A Mares - University of Wisconsin–Madison
Rick P Voland
Sherie A Sondel
Amy E Millen
Tara Larowe
Suzen M Moeller
Mike L Klein
Barbara A Blodi
Richard J Chappell
Lesley Tinker
Cheryl Ritenbaugh
Karen M Gehrs
Gloria E Sarto
Elizabeth Johnson - Tufts University
D Max Snodderly
Robert B Wallace
Resource Type: Journal article
Publication Details: Archives of ophthalmology (1960), Vol.129(4), pp.470-480
DOI: 10.1001/archophthalmol.2010.314
PMID: 21149749
PMCID: PMC3075357
NLM abbreviation: Arch Ophthalmol
ISSN: 0003-9950
eISSN: 1538-3601
Publisher: American Medical Association; United States
Grant note: N01WH42132 / WHI NIH HHS EY016886 / NEI NIH HHS N01WH42114 / WHI NIH HHS R01 EY016886-02 / NEI NIH HHS EY013018 / NEI NIH HHS U10 EY013018-03 / NEI NIH HHS N01WH32115 / WHI NIH HHS N01WH32102 / WHI NIH HHS N01WH24152 / WHI NIH HHS U10 EY013018 / NEI NIH HHS U10 EY013018-05 / NEI NIH HHS N01WH42117 / WHI NIH HHS N01WH44221 / WHI NIH HHS N01WH32105 / WHI NIH HHS N01WH32118 / WHI NIH HHS N01WH42122 / WHI NIH HHS N01WH42130 / WHI NIH HHS N01WH42112 / WHI NIH HHS N01WH42129 / WHI NIH HHS N01WH32122 / WHI NIH HHS N01WH32113 / WHI NIH HHS N01WH42121 / WHI NIH HHS N01WH42115 / WHI NIH HHS N01WH42124 / WHI NIH HHS N01WH42109 / WHI NIH HHS N01WH42123 / WHI NIH HHS N01WH32111 / WHI NIH HHS U10 EY013018-04 / NEI NIH HHS N01WH42118 / WHI NIH HHS R01 EY016886 / NEI NIH HHS N01WH42110 / WHI NIH HHS N01WH32106 / WHI NIH HHS N01WH32119 / WHI NIH HHS N01WH32101 / WHI NIH HHS N01WH42131 / WHI NIH HHS N01WH42108 / WHI NIH HHS N01WH42126 / WHI NIH HHS N01WH42113 / WHI NIH HHS N01WH32109 / WHI NIH HHS U10 EY013018-02 / NEI NIH HHS N01WH42107 / WHI NIH HHS N01WH42125 / WHI NIH HHS N01WH42116 / WHI NIH HHS N01WH32108 / WHI NIH HHS U10 EY013018-01 / NEI NIH HHS N01WH32100 / WHI NIH HHS N01WH32112 / WHI NIH HHS N01WH42119 / WHI NIH HHS N01WH22110 / WHI NIH HHS N01WH42111 / WHI NIH HHS N01WH42120 / WHI NIH HHS
Language: English
Date published: 04/2011
Academic Unit: Epidemiology; Injury Prevention Research Center; Internal Medicine; Ophthalmology and Visual Sciences
Record Identifier: 9983980022602771

Metrics

18 Record Views

125 Times Cited - Web of Science