Hearing suppression induced by electrical stimulation of human auditory cortex

Albert J Fenoy; Meryl A Severson; Igor O Volkov; John F Brugge; Matthew A Howard III

doi:10.1016/j.brainres.2006.08.013

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Hearing suppression induced by electrical stimulation of human auditory cortex

Journal article

Peer reviewed

Hearing suppression induced by electrical stimulation of human auditory cortex

Albert J Fenoy, Meryl A Severson, Igor O Volkov, John F Brugge and Matthew A Howard III

Brain research, Vol.1118(1), pp.75-83

11/06/2006

DOI: 10.1016/j.brainres.2006.08.013

PMCID: PMC3816378

PMID: 16979144

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https://www.ncbi.nlm.nih.gov/pmc/articles/3816378View

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Abstract

In the course of performing electrical stimulation functional mapping (ESFM) in neurosurgery patients, we identified three subjects who experienced hearing suppression during stimulation of sites within the superior temporal gyrus (STG). One of these patients had long standing tinnitus that affected both ears. In all subjects, auditory event related potentials (ERPs) were recorded from chronically implanted intracranial electrodes and the results were used to localize auditory cortical fields within the STG. Hearing suppression sites were identified within anterior lateral Heschl's gyrus (HG) and posterior lateral STG, in what may be auditory belt and parabelt fields. Cortical stimulation suppressed hearing in both ears, which persisted beyond the period of electrical stimulation. Subjects experienced other stimulation-evoked perceptions at some of these same sites, including symptoms of vestibular activation and alteration of audio-visual speech processing. In contrast, stimulation of presumed core auditory cortex within posterior medial HG evoked sound perceptions, or in one case an increase in tinnitus intensity, that affected the contralateral ear and did not persist beyond the period of stimulation. The current results confirm a rarely reported experimental observation, and correlate the cortical sites associated with hearing suppression with physiologically identified auditory cortical fields.

Electric Stimulation - adverse effects

Brain Mapping - instrumentation

Humans

Epilepsy - surgery

Hearing Loss, Central - etiology

Evoked Potentials - physiology

Male

Auditory Cortex - physiology

Brain Mapping - methods

Epilepsy - physiopathology

Auditory Perception - physiology

Illusions - physiology

Speech Perception - physiology

Neural Inhibition - physiology

Neurosurgical Procedures

Auditory Pathways - physiology

Evoked Potentials, Auditory - physiology

Tinnitus - etiology

Hearing Loss, Central - physiopathology

Adult

Female

Functional Laterality - physiology

Electric Stimulation - methods

Tinnitus - physiopathology

Details

Title: Subtitle: Hearing suppression induced by electrical stimulation of human auditory cortex
Creators: Albert J Fenoy - Department of Neurosurgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA. albert-fenoy@uiowa.edu
Meryl A Severson
Igor O Volkov
John F Brugge
Matthew A Howard III
Resource Type: Journal article
Publication Details: Brain research, Vol.1118(1), pp.75-83
DOI: 10.1016/j.brainres.2006.08.013
PMID: 16979144
PMCID: PMC3816378
NLM abbreviation: Brain Res
ISSN: 0006-8993
eISSN: 1872-6240
Publisher: Netherlands
Grant note: R01 DC04290 / NIDCD NIH HHS R01 DC004290 / NIDCD NIH HHS R01 DC004290-02 / NIDCD NIH HHS
Language: English
Date published: 11/06/2006
Academic Unit: Neurology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984020757202771

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