Journal article
Heart Rate Response to a Timed Walk & Cardiovascular Outcomes in Older Adults: The Cardiovascular Health Study
Cardiology, Vol.122(2), pp.69-75
2012
DOI: 10.1159/000338736
PMCID: PMC3516408
PMID: 22722364
Abstract
Objectives: To determine the relationship between heart rate response during low-grade physical exertion (6-min walk) with mortality and adverse cardiovascular outcomes in the elderly.
Methods: Participants in the Cardiovascular Health Study who completed a 6-min walk test were included. We used delta heart rate (difference between postwalk heart rate and resting heart rate) as a measure of chronotropic response and examined its association with (1) all-cause mortality and (2) incident coronary heart disease event, using multivariable Cox regression models.
Results: We included 2,224 participants (mean age 77 ± 4 years; 60% women; 85% white). The average delta heart rate was 26 beats/min. Participants in the lowest tertile of delta heart rate (<20 beats/min) had higher risk-adjusted mortality [hazard ratio (HR) 1.18, 95% confidence interval (CI) 1.00-1.40] and incident coronary heart disease (HR 1.37, 95% CI 1.05-1.78) compared to subjects in the highest tertile (≥30 beats/min), with a significant linear trend across tertiles (p for trend <0.05 for both outcomes). This relationship was not significant after adjustment for distance walked.
Conclusion: Impaired chronotropic response during a 6-min walk test was associated with an increased risk of mortality and incident coronary heart disease among the elderly. This association was attenuated after adjusting for distance walked.
Details
- Title: Subtitle
- Heart Rate Response to a Timed Walk & Cardiovascular Outcomes in Older Adults: The Cardiovascular Health Study
- Creators
- Saket Girotra - University of Iowa Hospitals & Clinics, Iowa City, IADalane W Kitzman - Wake Forest University Health Sciences; Winston-Salem, NCWillem J Kop - Tilburg University, The NetherlandsPhyllis K Stein - Washington University School of Medicine, St Louis, MOJohn S Gottdiener - University of Maryland Medical Center, Baltimore, MDKenneth J Mukamal - Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
- Resource Type
- Journal article
- Publication Details
- Cardiology, Vol.122(2), pp.69-75
- DOI
- 10.1159/000338736
- PMID
- 22722364
- PMCID
- PMC3516408
- ISSN
- 0008-6312
- eISSN
- 1421-9751
- Grant note
- R01 HL062181 || HL / National Heart, Lung, and Blood Institute : NHLBI R37 AG018915 || AG / National Institute on Aging : NIA P30 AG021332 || AG / National Institute on Aging : NIA
- Language
- English
- Date published
- 2012
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094777902771
Metrics
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