Journal article
Heart Transplantation in Children With Down Syndrome
Journal of the American Heart Association, Vol.11(10), pp.e024883-e024883
05/17/2022
DOI: 10.1161/JAHA.121.024883
PMCID: PMC9238550
PMID: 35574952
Abstract
Background Children with Down syndrome (DS) have a high risk of cardiac disease that may prompt consideration for heart transplantation (HTx). However, transplantation in patients with DS is rarely reported. This project aimed to collect and describe waitlist and post– HTx outcomes in children with DS. Methods and Results This is a retrospective case series of children with DS listed for HTx. Pediatric HTx centers were identified by their participation in 2 international registries with centers reporting HTx in a patient with DS providing detailed demographic, medical, surgical, and posttransplant outcome data for analysis. A total of 26 patients with DS were listed for HTx from 1992 to 2020 (median age, 8.5 years; 46% male). High‐risk or failed repair of congenital heart disease was the most common indication for transplant (N=18, 69%). A total of 23 (88%) patients survived to transplant. All transplanted patients survived to hospital discharge with a median posttransplant length of stay of 22 days. At a median posttransplant follow‐up of 2.8 years, 20 (87%) patients were alive, 2 (9%) developed posttransplant lymphoproliferative disorder, and 8 (35%) were hospitalized for infection within the first year. Waitlist and posttransplant outcomes were similar in patients with and without DS ( P =non‐significant for all). Conclusions Waitlist and post‐HTx outcomes in children with DS selected for transplant listing are comparable to pediatric HTx recipients overall. Given acceptable outcomes, the presence of DS alone should not be considered an absolute contraindication to HTx.
Details
- Title: Subtitle
- Heart Transplantation in Children With Down Syndrome
- Creators
- Justin Godown - Monroe Carell Jr. Children's HospitalDarlene Fountain - Monroe Carell Jr. Children's HospitalNeha Bansal - Children's Hospital at MontefioreRebecca Ameduri - University of MinnesotaSusan Anderson - University of MinnesotaGary Beasley - Le Bonheur Children's HospitalDanielle Burstein - Children's Hospital of PhiladelphiaKenneth Knecht - Arkansas Children's HospitalKimberly Molina - Primary Children's HospitalSherry Pye - Arkansas Children's HospitalMarc Richmond - Columbia University Irving Medical CenterJoseph A. Spinner - Texas Children's HospitalKae Watanabe - Lurie Children's HospitalShawn West - Children's Hospital of PittsburghZdenka Reinhardt - Freeman HospitalJanet Scheel - Washington University in St. LouisSimon Urschel - University of AlbertaChet Villa - Cincinnati Children's Hospital Medical CenterSeth A. Hollander - Stanford University
- Resource Type
- Journal article
- Publication Details
- Journal of the American Heart Association, Vol.11(10), pp.e024883-e024883
- DOI
- 10.1161/JAHA.121.024883
- PMID
- 35574952
- PMCID
- PMC9238550
- ISSN
- 2047-9980
- eISSN
- 2047-9980
- Language
- English
- Date published
- 05/17/2022
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984353935702771
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