Journal article
Heart failure and the brain: new perspectives
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.284(2), pp.R259-R276
02/01/2003
DOI: 10.1152/ajpregu.00317.2002
PMID: 12529279
Abstract
Despite recent therapeutic advances, the prognosis for patients with heart failure remains dismal. Unchecked neurohumoral excitation is a critical element in the progressive clinical deterioration associated with the heart failure syndrome, and its peripheral manifestations have become the principal targets for intervention. The link between peripheral systems activated in heart failure and the central nervous system as a source of neurohumoral drive has therefore come under close scrutiny. In this context, the forebrain and particularly the paraventricular nucleus of the hypothalamus have emerged as sites that sense humoral signals generated peripherally in response to the stresses of heart failure and contribute to the altered volume regulation and augmented sympathetic drive that characterize the heart failure syndrome. This brief review summarizes recent studies from our laboratory supporting the concept that the forebrain plays a critical role in the pathogenesis of ischemia-induced heart failure and suggesting that the forebrain contribution must be considered in designing therapeutic strategies. Forebrain signaling by neuroactive products of the renin-angiotensin system and the immune system are emphasized.
Details
- Title: Subtitle
- Heart failure and the brain: new perspectives
- Creators
- Robert B Felder - Departments of Internal Medicine and, Research Service, Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242Joseph Francis - Departments of Internal Medicine andZhi-Hua Zhang - Departments of Internal Medicine andShun-Guang Wei - Departments of Internal Medicine andRobert M Weiss - Departments of Internal Medicine and, Research Service, Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242Alan Kim Johnson - Psychology and Cardiovascular Center, University of Iowa and
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.284(2), pp.R259-R276
- DOI
- 10.1152/ajpregu.00317.2002
- PMID
- 12529279
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 02/01/2003
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Cardiovascular Medicine; Neuroscience and Pharmacology; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984065390002771
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