Journal article
Heart rate and early progression of cardiac allograft vasculopathy: A prospective study using highly automated 3‐D optical coherence tomography analysis
Clinical transplantation, Vol.34(2), pp.e13773-n/a
02/2020
DOI: 10.1111/ctr.13773
PMCID: PMC7220813
PMID: 31859379
Abstract
Introduction
Heart rate slowing agents are frequently prescribed to manage heart transplant (HTx) patients with the assumption that higher heart rate is a risk factor in cardiovascular disease.
Patients and Methods
This prospective two‐center study investigated early progression of cardiac allograft vasculopathy (CAV) in 116 HTx patients. Examinations by coronary optical coherence tomography and 24‐hour ambulatory ECG monitoring were performed both at baseline (1 month after HTx) and during follow‐up (12 months after HTx).
Results
During the first post‐HTx year, we observed a significant reduction in the mean coronary luminal area from 9.0 ± 2.5 to 8.0 ± 2.4 mm2 (P < .001), and progression in mean intimal thickness (IT) from 106.5 ± 40.4 to 130.1 ± 53.0 µm (P < .001). No significant relationship was observed between baseline and follow‐up mean heart rates and IT progression (R = .02, P = .83; R = −.13, P = .18). We found a mild inverse association between beta‐blocker dosage at 12 months and IT progression (R = −.20, P = .035).
Conclusion
Our study did not confirm a direct association between mean heart rate and progression of CAV. The role of beta blockers warrants further investigation, with our results indicating that they may play a protective role in early CAV development.
Details
- Title: Subtitle
- Heart rate and early progression of cardiac allograft vasculopathy: A prospective study using highly automated 3‐D optical coherence tomography analysis
- Creators
- Michal Pazdernik - Charles UniversityDan Wichterle - Charles UniversityZhi Chen - University of IowaHelena Bedanova - Cardiovascular and Transplantation Surgery Brno Czech RepublicJosef Kautzner - Department of Cardiology IKEM Prague Czech RepublicVojtech Melenovsky - Department of Cardiology IKEM Prague Czech RepublicVladimir Karmazin - Department of Cardiology IKEM Prague Czech RepublicIvan Malek - Department of Cardiology IKEM Prague Czech RepublicPeter Stiavnicky - Department of Cardiology IKEM Prague Czech RepublicAles Tomasek - Cardiovascular and Transplantation Surgery Brno Czech RepublicEva Ozabalova - Masaryk UniversityJan Krejci - Masaryk UniversityAndreas Wahle - University of IowaHonghai Zhang - University of IowaTomas Kovarnik - Charles UniversityMilan Sonka - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical transplantation, Vol.34(2), pp.e13773-n/a
- DOI
- 10.1111/ctr.13773
- PMID
- 31859379
- PMCID
- PMC7220813
- NLM abbreviation
- Clin Transplant
- ISSN
- 0902-0063
- eISSN
- 1399-0012
- Number of pages
- 9
- Grant note
- Czech Ministry of Health (16‐27465A) Foundation for the National Institutes of Health (R01‐EB004640)
- Language
- English
- Date published
- 02/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984186597702771
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