Journal article
Heat-induced cytotoxicity in H2O2-resistant Chinese hamster fibroblasts
Journal of cellular physiology, Vol.142(2), pp.255-260
02/1990
DOI: 10.1002/jcp.1041420206
PMID: 2303525
Abstract
Hydrogen-peroxide-resistant Chinese hamster fibroblasts, derived from the HA-1 cell line, were isolated following continuous culturing in the presence of progressively increasing concentrations of hydrogen peroxide. The hydrogen-peroxide-resistant phenotype has been stable for over 360 days following removal from H2 O2 stress. These H2 O2-resisant cell lines demonstrate increased resistance to hyperthermic cell killing, mediated by continuous heating at 43°C but not 45°C. The relationship between mammalian cellular adaptation to oxidative stress mediated by H2 O2 and resistance to 43°C hyperthermia is discussed.
Details
- Title: Subtitle
- Heat-induced cytotoxicity in H2O2-resistant Chinese hamster fibroblasts
- Creators
- Douglas R. Spitz - University of VirginiaGloria C. Li - University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- Journal of cellular physiology, Vol.142(2), pp.255-260
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/jcp.1041420206
- PMID
- 2303525
- ISSN
- 0021-9541
- eISSN
- 1097-4652
- Number of pages
- 6
- Language
- English
- Date published
- 02/1990
- Academic Unit
- Pathology; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984312975902771
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