Heat shock protein response in a prostate tumor model to interstitial thermotherapy: implications for clinical treatment

J A Paulus; R D Tucker; S W Flanagan; P L Moseley; S A Loening; J B Park

doi:10.1002/pros.2990230308

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Heat shock protein response in a prostate tumor model to interstitial thermotherapy: implications for clinical treatment

Journal article

Peer reviewed

Heat shock protein response in a prostate tumor model to interstitial thermotherapy: implications for clinical treatment

J A Paulus, R D Tucker, S W Flanagan, P L Moseley, S A Loening and J B Park

The Prostate, Vol.23(3), pp.263-270

1993

DOI: 10.1002/pros.2990230308

PMID: 8234068

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Abstract

Hyperthermia is being utilized individually and in conjunction with other therapies in treating malignant and benign tumors, though few studies have examined cellular effects of elevated temperatures in the prostate model. Highly conserved proteins of the 70 kDa heat shock protein family (HSP 70) are produced in response to environmental stresses, including heat, and are found in all organisms. HSPs are an indicator of cell damage, are associated with thermotolerance, and provide cells with transient resistance to subsequent thermal challenges. Transient thermotolerance is important in the determination of temperature, duration, and sequencing for treatments. This preliminary study analyzes the HSP 70 response of the Dunning R3327 adenocarcinoma model to a single 50 degrees C 1 hr treatment. Elevated HSP levels were found between 10 and 16 hr, returning to baseline by 24 hr. As some fractions of the cells are able to produce HSP 70 following treatment, the data suggest that currently utilized clinical temperatures (42-46 degrees C) administered for 1 hr are inadequate. HSP levels in response to hyperthermia, radiation, and chemotherapy may be useful in finding optimal treatment regimens for prostate cancer.

Neoplasm Transplantation

Prostatic Neoplasms - metabolism

Prostatic Neoplasms - pathology

Adenocarcinoma - pathology

Heat-Shock Proteins - metabolism

Rats

Male

Blotting, Western

Prostatic Neoplasms - therapy

Adenocarcinoma - metabolism

Animals

Adenocarcinoma - therapy

Hyperthermia, Induced

Details

Title: Subtitle: Heat shock protein response in a prostate tumor model to interstitial thermotherapy: implications for clinical treatment
Creators: J A Paulus - Department of Biomedical Engineering, University of Iowa, Iowa City 52242
R D Tucker
S W Flanagan
P L Moseley
S A Loening
J B Park
Resource Type: Journal article
Publication Details: The Prostate, Vol.23(3), pp.263-270
Publisher: United States
DOI: 10.1002/pros.2990230308
PMID: 8234068
ISSN: 0270-4137
eISSN: 1097-0045
Language: English
Date published: 1993
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pathology; Health and Human Physiology
Record Identifier: 9984047862102771

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