Heat stress stimulates hepcidin mRNA expression and C/EBPα protein expression in aged rodent liver

Steven A Bloomer; Kevin C Kregel; Kyle E Brown

doi:10.1016/j.archger.2013.07.012

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Heat stress stimulates hepcidin mRNA expression and C/EBPα protein expression in aged rodent liver

Journal article

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Heat stress stimulates hepcidin mRNA expression and C/EBPα protein expression in aged rodent liver

Steven A Bloomer, Kevin C Kregel and Kyle E Brown

Archives of gerontology and geriatrics, Vol.58(1), pp.145-152

01/2014

DOI: 10.1016/j.archger.2013.07.012

PMCID: PMC3808518

PMID: 23993269

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Abstract

Elevations in hepatic iron content occur with aging and physiological stressors, which may promote oxidative injury to the liver. Since dysregulation of the iron regulatory hormone, hepcidin, can cause iron accumulation, our goal was to characterize the regulation of hepcidin in young (6 mo) and old (24 mo) Fischer 344 rats exposed to environmental heat stress. Liver and blood samples were taken in the control condition and after heating. Hepcidin expression did not differ between young and old rats in the control condition, despite higher levels of hepatic iron and IL-6 mRNA in the latter. Following heat stress, pSTAT3 increased in both groups, but C/EBPα and hepcidin mRNA increased only in old rats. Despite this, serum iron decreased in both age groups 2h after heat stress, suggesting hepcidin-independent hypoferremia in the young rats. The differential regulation of hepcidin between young and old rats after hyperthermia may be due to the enhanced expression of C/EBPα protein in old rats. These data support the concept of “inflammaging” and suggest that repeated exposures to stressors may contribute to the development of anemia in older individuals.

Iron

Inflammation

IL-6

Hypoferremia

STAT3

Details

Title: Subtitle: Heat stress stimulates hepcidin mRNA expression and C/EBPα protein expression in aged rodent liver
Creators: Steven A Bloomer - Division of Science and Engineering, Penn State Abington College, Abington, PA, United States
Kevin C Kregel - Department of Health and Human Physiology, The University of Iowa, Iowa City, IA 52242, United States
Kyle E Brown - Iowa City Veterans Administration Medical Center, Iowa City, IA 52242, United States
Resource Type: Journal article
Publication Details: Archives of gerontology and geriatrics, Vol.58(1), pp.145-152
DOI: 10.1016/j.archger.2013.07.012
PMID: 23993269
PMCID: PMC3808518
NLM abbreviation: Arch Gerontol Geriatr
ISSN: 0167-4943
eISSN: 1872-6976
Publisher: Elsevier Ireland Ltd
Language: English
Date published: 01/2014
Academic Unit: Gastroenterology and Hepatology; Radiation Oncology; Provost Office Administration; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984047624202771

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