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Heck reaction with an acyl synthon: new coupling reaction between α-halo vinyl ether and alkene
Journal article   Peer reviewed

Heck reaction with an acyl synthon: new coupling reaction between α-halo vinyl ether and alkene

Xiaobang Gao, Wensheng Yu, Yan Mei and Zhendong Jin
Tetrahedron letters, Vol.45(44), pp.8169-8171
2004
DOI: 10.1016/j.tetlet.2004.09.029

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Abstract

α-Halo vinyl ethers were successfully applied to palladium-catalyzed Heck reaction. α-Halo vinyl ethers were successfully applied to palladium-catalyzed Heck reaction. Reactions of α-halo vinyl ether with alkenes under various Heck conditions form a new carbon–carbon bond along with a vinyl ether functionality, which can be further manipulated. This is the first synthetic methodology for the coupling of an acyl synthon with alkene employing Heck reaction.
Heck reaction Masked ketone Vinyl ether α-Halo vinyl ether

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