Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate

Ellen van der Plas; Chelsea J Caspell; Andrea M Aerts; Eva Tsalikian; Lynn C Richman; Jeffrey D Dawson; Peg Nopoulos

doi:10.1038/pr.2012.12

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Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate

Journal article

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Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate

Ellen van der Plas, Chelsea J Caspell, Andrea M Aerts, Eva Tsalikian, Lynn C Richman, Jeffrey D Dawson and Peg Nopoulos

Pediatric research, Vol.71(5), pp.612-618

05/2012

DOI: 10.1038/pr.2012.12

PMCID: PMC3637911

PMID: 22322386

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Abstract

Individuals with isolated cleft lip and/or palate (ICLP) are often reported to be of shorter stature relative to peers, and the objective of this study was to explore the role of the pituitary in relationship to growth. Fifty-five males and 32 females with ICLP were compared to 121 healthy males and 158 healthy females with respect to height and BMI. Magnetic resonance imaging (MRI) scans were obtained from all ICLP participants and 47% of healthy group participants. Males with ICLP were shorter than healthy males and had lower BMI. However, the trajectories for height and BMI did not differ between groups. Analyses in a separate sample of adult males suggested that height normalizes in males with ICLP in their early 30s. There were no differences in mean pituitary volume and pituitary trajectories between male groups. Females with ICLP were shorter than healthy females and also had slower growth rates. They did not differ in mean BMI or BMI trajectories. Furthermore, there were no differences in mean pituitary volume, or in pituitary trajectories. Our findings suggest that there are no gross morphological differences in pituitary volume in individuals with ICLP, although more subtle differences may exist.

Body Mass Index

Pituitary Gland - pathology

Humans

Male

Pituitary Gland - anatomy & histology

Case-Control Studies

Young Adult

Cleft Lip - pathology

Cleft Palate - pathology

Adolescent

Adult

Body Height

Female

Child

Details

Title: Subtitle: Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate
Creators: Ellen van der Plas - Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA. ellen-vanderplas@uiowa.edu
Chelsea J Caspell
Andrea M Aerts
Eva Tsalikian
Lynn C Richman
Jeffrey D Dawson
Peg Nopoulos
Resource Type: Journal article
Publication Details: Pediatric research, Vol.71(5), pp.612-618
DOI: 10.1038/pr.2012.12
PMID: 22322386
PMCID: PMC3637911
NLM abbreviation: Pediatr Res
ISSN: 0031-3998
eISSN: 1530-0447
Publisher: United States
Grant note: R01 DE014399 / NIDCR NIH HHS
Language: English
Date published: 05/2012
Academic Unit: Neurology; Public Health Administration; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics
Record Identifier: 9983997457302771

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