Journal article
Helicobacter pylori Seropositivity, ABO Blood Type, and Pancreatic Cancer Risk from 5 Prospective Cohorts
Clinical and translational gastroenterology, Vol.14(5), e00573
03/01/2023
DOI: 10.14309/ctg.0000000000000573
PMCID: PMC10208692
PMID: 36854058
Abstract
BACKGROUND:
Helicobacter pylori infection may be a risk factor for pancreatic cancer, particularly infection by strains without the cytotoxin-associated gene A (CagA) virulence factor. Non-O blood type is a known risk factor for pancreatic cancer, and H. pylori gastric colonization occurs largely from bacterial adhesins binding to blood group antigens on gastric mucosa.
METHODS:
We included 485 pancreatic cancer cases and 1,122 matched controls from 5 U.S. prospective cohorts. Prediagnostic plasma samples were assessed for H. pylori and CagA antibody titers. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for pancreatic cancer. ABO blood type was assessed using genetic polymorphisms at the ABO gene locus or self-report.
RESULTS:
Compared with H. pylori–seronegative participants, those who were seropositive did not demonstrate an increased risk of pancreatic cancer (OR 0.83, 95% CI 0.65–1.06). This lack of association was similar among CagA-seropositive (OR 0.75, 95% CI 0.53–1.04) and -seronegative (OR 0.89, 95% CI 0.65–1.20) participants. The association was also similar when stratified by time between blood collection and cancer diagnosis (P-interaction = 0.80). Consistent with previous studies, non-O blood type was associated with increased pancreatic cancer risk, but this increase in risk was similar regardless of H. pylori seropositivity (P-interaction = 0.51).
DISCUSSION:
In this nested case-control study, history of H. pylori infection as determined by H. pylori antibody serology was not associated with pancreatic cancer risk, regardless of CagA virulence factor status. The elevated risk associated with non-O blood type was consistent in those with or without H. pylori seropositivity.
Details
- Title: Subtitle
- Helicobacter pylori Seropositivity, ABO Blood Type, and Pancreatic Cancer Risk from 5 Prospective Cohorts
- Creators
- Alice A. Lee - Brigham and Women's HospitalQiao-Li Wang - Dana-Farber Cancer InstituteJihye Kim - Harvard UniversityAna Babic - Dana-Farber Cancer InstituteXuehong Zhang - Harvard UniversityKimberly Perez - Dana-Farber Cancer InstituteKimmie Ng - Dana-Farber Cancer InstituteJonathan Nowak - Brigham and Women's HospitalNader Rifai - Harvard UniversityHoward D. Sesso - Brigham and Women's HospitalJulie E. Buring - Harvard UniversityGarnet L. Anderson - Fred Hutch Cancer CenterJean Wactawski-Wende - University at Buffalo, State University of New YorkRobert Wallace - University of IowaJoAnn E. Manson - Brigham and Women's HospitalEdward L. Giovannucci - Harvard UniversityMeir J. Stampfer - Harvard UniversityPeter Kraft - Harvard UniversityCharles S. Fuchs - RocheChen Yuan - Dana-Farber Cancer InstituteBrian M. Wolpin - Harvard University
- Resource Type
- Journal article
- Publication Details
- Clinical and translational gastroenterology, Vol.14(5), e00573
- DOI
- 10.14309/ctg.0000000000000573
- PMID
- 36854058
- PMCID
- PMC10208692
- NLM abbreviation
- Clin Transl Gastroenterol
- ISSN
- 2155-384X
- eISSN
- 2155-384X
- Publisher
- Wolters Kluwer
- Grant note
- National Institutes of Health (NIH): U01 CA167552 NIH: UM1 CA186107, P01 CA87969, R01 CA49449, R01 CA097193, CA 34944, CA 40360, HL 26490, HL 34595, HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C, R01 CA047988, R01 HL043851, R01 HL080467, R01 CA205406, U01 CA210171, P50 CA127003 Broman Fund for Pancreatic Cancer ResearchHale Family Center for Pancreatic Cancer ResearchLustgarten Foundation Dedicated Laboratory Program, Stand Up To CancerPancreatic Cancer Action NetworkNoble Effort FundWexler Family Fund
The Health Professionals Follow-up Study is supported by the National Institutes of Health (NIH) grant U01 CA167552. The Nurses' Health Study is supported by the NIH grants UM1 CA186107, P01 CA87969, and R01 CA49449. The Physicians' Health Study is supported by the NIH grants R01 CA097193, CA 34944, CA 40360, HL 26490, and HL 34595. The Women's Health Initiative program is funded by NIH through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. The Women's Health Study is supported by the NIH grants R01 CA047988, R01 HL043851, and R01 HL080467. This work was additionally supported by the NIH grant R01 CA205406 and the Broman Fund for Pancreatic Cancer Research to K.N.; by NIH grant U01 CA210171, NIH grant P50 CA127003, Hale Family Center for Pancreatic Cancer Research, Lustgarten Foundation Dedicated Laboratory Program, Stand Up To Cancer, Pancreatic Cancer Action Network, Noble Effort Fund, Wexler Family Fund, Parsons Fund for Pancreatic Cancer Early Detection, and Promises for Purple to B.M.W. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
- Language
- English
- Date published
- 03/01/2023
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984748154402771
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