Journal article
Help, hinder, hide and harm: what can we learn from the interactions between Pseudomonas aeruginosa and Staphylococcus aureus during respiratory infections?
Thorax, Vol.74(7), pp.684-692
07/01/2019
DOI: 10.1136/thoraxjnl-2018-212616
PMCID: PMC6585302
PMID: 30777898
Abstract
Recent studies of human respiratory secretions using culture-independent techniques have found a surprisingly diverse array of microbes. Interactions among these community members can profoundly impact microbial survival, persistence and antibiotic susceptibility and, consequently, disease progression. Studies of polymicrobial interactions in the human microbiota have shown that the taxonomic and structural compositions, and resulting behaviours, of microbial communities differ substantially from those of the individual constituent species and in ways of clinical importance. These studies primarily involved oral and gastrointestinal microbiomes. While the field of polymicrobial respiratory disease is relatively young, early findings suggest that respiratory tract microbiota members also compete and cooperate in ways that may influence disease outcomes. Ongoing efforts therefore focus on how these findings can inform more 'enlightened', rational approaches to combat respiratory infections. Among the most common respiratory diseases involving polymicrobial infections are cystic fibrosis (CF), non-CF bronchiectasis, COPD and ventilator-associated pneumonia. While respiratory microbiota can be diverse, two of the most common and best-studied members are Staphylococcus aureus and Pseudomonas aeruginosa, which exhibit a range of competitive and cooperative interactions. Here, we review the state of research on pulmonary coinfection with these pathogens, including their prevalence, combined and independent associations with patient outcomes, and mechanisms of those interactions that could influence lung health. Because P. aeruginosa-S. aureus coinfection is common and well studied in CF, this disease serves as the paradigm for our discussions on these two organisms and inform our recommendations for future studies of polymicrobial interactions in pulmonary disease.
Details
- Title: Subtitle
- Help, hinder, hide and harm: what can we learn from the interactions between Pseudomonas aeruginosa and Staphylococcus aureus during respiratory infections?
- Creators
- Dominique Hope Limoli - Roy J. and Lucille A. Carver College of MedicineLucas R. Hoffman - University of Washington
- Resource Type
- Journal article
- Publication Details
- Thorax, Vol.74(7), pp.684-692
- DOI
- 10.1136/thoraxjnl-2018-212616
- PMID
- 30777898
- PMCID
- PMC6585302
- NLM abbreviation
- Thorax
- ISSN
- 0040-6376
- eISSN
- 1468-3296
- Publisher
- Bmj Publishing Group
- Number of pages
- 9
- Grant note
- LIMOLI18F5 / Cystic Fibrosis Foundation; Italian Cystic Fibrosis Research Foundation K24HL141669 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30DK089507 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 07/01/2019
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984297325402771
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