Journal article
Hematoporphyrin Photoradiation Therapy for Iris Neovascularization: A Preliminary Report
Archives of ophthalmology (1960), Vol.102(8), pp.1193-1197
08/01/1984
DOI: 10.1001/archopht.1984.01040030971028
PMID: 6205648
Abstract
• Photoradiation therapy is a new technique currently under clinical investigation for the treatment of a variety of solid malignant tumors. The technique involves intravenous (IV) administration of hematoporphyrin derivative, a photosensitizing compound that is preferentially retained by malignant cells, and photoactivation of a neoplasm with red light (630 nm) to obtain selective destruction of cancer cells. A modification of this technique was used to treat iris neovascularization produced in a primate model of retinal vein occlusion. Following IV injection of hematoporphyrin derivative, the anterior surface of the iris was exposed to red light for 30 to 45 minutes. In the four eyes treated, there was a marked reduction of fluorescein leakage from the neovascular tissue within 24 hours following treatment. Histologic examination of two eyes demonstrated a selective response of the iris neovascularization to this therapy, with apparent preservation of surrounding tissue.
Details
- Title: Subtitle
- Hematoporphyrin Photoradiation Therapy for Iris Neovascularization: A Preliminary Report
- Creators
- Andrew J Packer - University of IowaDavid T Tse - University of IowaXun-Qing GuSohan Singh Hayreh - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Archives of ophthalmology (1960), Vol.102(8), pp.1193-1197
- DOI
- 10.1001/archopht.1984.01040030971028
- PMID
- 6205648
- NLM abbreviation
- Arch Ophthalmol
- ISSN
- 0003-9950
- eISSN
- 1538-3601
- Publisher
- American Medical Association
- Language
- English
- Date published
- 08/01/1984
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984182759302771
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