Journal article
Heme Uptake and Utilization by Gram-Negative Bacterial Pathogens
Frontiers in cellular and infection microbiology, Vol.9, pp.81-81
03/29/2019
DOI: 10.3389/fcimb.2019.00081
PMCID: PMC6449446
PMID: 30984629
Abstract
Iron is a transition metal utilized by nearly all forms of life for essential cellular processes, such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the host utilizes various strategies to sequester iron in a process termed, nutritional immunity. To circumvent these defenses, Gram-negative pathogens have evolved numerous mechanisms to obtain iron from heme. In this review we outline the systems that exist in several Gram-negative pathogens that are associated with heme transport and utilization, beginning with hemolysis and concluding with heme degradation. In addition, Gram-negative pathogens must also closely regulate the intracellular concentrations of iron and heme, since high levels of iron can lead to the generation of toxic reactive oxygen species. As such, we also provide several examples of regulatory pathways that control heme utilization, showing that co-regulation with other cellular processes is complex and often not completely understood.
Details
- Title: Subtitle
- Heme Uptake and Utilization by Gram-Negative Bacterial Pathogens
- Creators
- Kaylie L. Richard - University of Tennessee at KnoxvilleBrittni R. Kelley - University of Tennessee at KnoxvilleJeremiah G. Johnson - University of Tennessee at Knoxville
- Resource Type
- Journal article
- Publication Details
- Frontiers in cellular and infection microbiology, Vol.9, pp.81-81
- Publisher
- Frontiers Media S.A
- DOI
- 10.3389/fcimb.2019.00081
- PMID
- 30984629
- PMCID
- PMC6449446
- ISSN
- 2235-2988
- eISSN
- 2235-2988
- Language
- English
- Date published
- 03/29/2019
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984696570802771
Metrics
3 Record Views