Heme and HO-1 Inhibition of HCV, HBV, and HIV

Warren N Schmidt; M. Meleah Mathahs; Zhaowen Zhu

doi:10.3389/fphar.2012.00129

Back

Heme and HO-1 Inhibition of HCV, HBV, and HIV

Journal article

Open access

Peer reviewed

Heme and HO-1 Inhibition of HCV, HBV, and HIV

Warren N Schmidt, M. Meleah Mathahs and Zhaowen Zhu

Frontiers in pharmacology, Vol.3, pp.129-129

2012

DOI: 10.3389/fphar.2012.00129

PMCID: PMC3463857

PMID: 23060790

Files and links (1)

url

https://doi.org/10.3389/fphar.2012.00129View

Published (Version of record) Open Access

Abstract

Hepatitis C virus, human immunodeficiency virus, and hepatitis B virus are chronic viral infections that cause considerable morbidity and mortality throughout the world. In the decades following the identification and sequencing of these viruses, in vitro experiments demonstrated that heme oxygenase-1, its oxidative products, and related compounds of the heme oxygenase system inhibit replication of all 3 viruses. The purpose of this review is to critically evaluate and summarize the seminal studies that described and characterized this remarkable behavior. It will also discuss more recent work that discovered the antiviral mechanisms and target sites of these unique antiviral agents. In spite of the fact that these viruses are diverse pathogens with quite profound differences in structure and life cycle, it is significant that heme and related compounds show striking similarity for viral target sites across all three species. Collectively, these findings strongly indicate that we should move forward and develop heme and related tetrapyrroles into versatile antiviral agents that could be used therapeutically in patients with single or multiple viral infections.

viruses

HIV

biliverdin

Heme

proteases

Pharmacology

HCV

HBV

metalloporphyrins

Details

Title: Subtitle: Heme and HO-1 Inhibition of HCV, HBV, and HIV
Creators: Warren N Schmidt - Department of Internal Medicine and Research Service, Veterans Affairs Medical Center, University of Iowa
M. Meleah Mathahs - Department of Internal Medicine and Research Service, Veterans Affairs Medical Center, University of Iowa
Zhaowen Zhu - Department of Internal Medicine and Research Service, Veterans Affairs Medical Center, University of Iowa
Resource Type: Journal article
Publication Details: Frontiers in pharmacology, Vol.3, pp.129-129
DOI: 10.3389/fphar.2012.00129
PMID: 23060790
PMCID: PMC3463857
NLM abbreviation: Front Pharmacol
ISSN: 1663-9812
eISSN: 1663-9812
Publisher: Frontiers Research Foundation
Language: English
Date published: 2012
Academic Unit: Dermatology; Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094212102771

Metrics

17 Record Views

41 Times Cited - Web of Science