Journal article
Hemodynamic Response to Normovolemic Polycythemia at Rest and during Exercise in Dogs
Circulation research, Vol.56(6), pp.793-800
06/1985
DOI: 10.1161/01.RES.56.6.793
PMID: 4006091
Abstract
Very little is known about the influence of polycythemia on oxygen transport during exercise. We studied chronically instrumented dogs trained to run on a treadmill before and after their hematocrit had been increased by isolvolemic exchange transfusion with packed red blood cells. With normovolemic polycythemia, cardiac output fell in a linear fashion as hematocrit was increased to 65%, but these changes were balanced by an increasing oxygen content resulting in constant systemic oxygen transport. Oxgen consumption was unchanged both at rest and during exercise after induction of polycythemia. To investigate the effect of polycythemia on oxygen transport further, we measured both mixed venous Po2 and lactate. Mixed venous Po2 increased and lactate remained unchanged both at rest and in exercising polycythemic dogs. Thus, we conclude that, in conscious animals, systemic oxygen transport is well preserved with increasing hematocrit to at least 65%.
Details
- Title: Subtitle
- Hemodynamic Response to Normovolemic Polycythemia at Rest and during Exercise in Dogs
- Creators
- JoAnn Lindenfeld - Linde (United States)John WeilVictoria Travis - University of Colorado DenverLawrence Horwitz
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.56(6), pp.793-800
- DOI
- 10.1161/01.RES.56.6.793
- PMID
- 4006091
- NLM abbreviation
- Circ Res
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Publisher
- American Heart Association, Inc
- Language
- English
- Date published
- 06/1985
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656610902771
Metrics
4 Record Views