Journal article
Hemodynamic analysis of thrombosed intracranial aneurysms: a comparative correlation study
Neurosurgical review, Vol.48(1), 417
05/14/2025
DOI: 10.1007/s10143-025-03566-2
PMCID: PMC12078405
PMID: 40369300
Appears in UI Libraries Support Open Access
Abstract
A small fraction of intracranial aneurysms (IA) contains intrasaccular thrombosis (IST). This study explores the hemodynamic causes of IST formation in IAs. We performed computational hemodynamic analysis in 26 IAs: 13 thrombosed and 13 non-thrombosed. The IAs in the two cohorts were matching in size and anatomical location. The computational hemodynamic analysis used "patient-specific" IA geometries derived from 3D magnetic resonance imaging. A comprehensive hemodynamic analysis was conducted using commonly used hemodynamic metrics (e.g., wall shear stress [WSS] and its derivative), flow vortex analysis, and velocity informatics. We observed that more flow eddies and endothelial cell activation potential (ECAP) are present in thrombosed IAs. The flow eddies in thrombosed IAs change size and location over a cardiac cycle more significantly than those in non-thrombosed IAs. These two factors, coupled with more flow stagnation and positive WSS divergence in the thrombosed IAs, promoted thrombus formation in the thrombosed IA cohort.
Details
- Title: Subtitle
- Hemodynamic analysis of thrombosed intracranial aneurysms: a comparative correlation study
- Creators
- Zonghan Lyu - Michigan Technological UniversityAndres Gudino - University of IowaCarlos Dier - University of IowaElena Sagues - University of IowaIvonne Salinas - University of Iowa, NeurologyGustavo Chiriboga - University of Iowa, NeurologyShubhangi Setia - University of IowaNavami Shenoy - University of IowaEdgar A Samaniego - Department of Neurosurgery, University of Iowa, Iowa City, IA, 52242, USA. edgar-samaniego@uiowa.eduJingfeng Jiang - Michigan Technological University
- Resource Type
- Journal article
- Publication Details
- Neurosurgical review, Vol.48(1), 417
- DOI
- 10.1007/s10143-025-03566-2
- PMID
- 40369300
- PMCID
- PMC12078405
- NLM abbreviation
- Neurosurg Rev
- ISSN
- 1437-2320
- eISSN
- 1437-2320
- Publisher
- Springer Nature
- Grant note
- R01-EB029570A1 / US National Institutes of Health R01 EB029570 / NIBIB NIH HHS
- Language
- English
- Date published
- 05/14/2025
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984823068002771
Metrics
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