Journal article
Hemodynamic consequences of neuropeptide Y-induced obesity
American journal of hypertension, Vol.15(2), pp.137-142
2002
DOI: 10.1016/S0895-7061(01)02270-1
PMID: 11865825
Abstract
Acute central nervous system administration of neuropeptide Y (NPY) elicits variable hemodynamic responses. Chronic intracerebroventricular (ICV) administration of NPY produces obesity in rats. Obesity has been shown to increase arterial pressure.
In this study we examined the chronic hemodynamic effects of NPY-induced obesity. Sprague-Dawley rats were implanted with radiotelemetry transmitters to continuously record heart rate and arterial pressure in the conscious state. Neuropeptide Y or vehicle was delivered into the third cerebral ventricle by osmotic minipumps over 2 weeks. Three groups were studied: vehicle, NPY-treated (free-fed), and NPY-treated (pair-fed to vehicle-treated rats).
Neuropeptide Y increased food intake and body weight in free-fed animals, and substantially augmented visceral adiposity in both free- and pair-fed rats. Despite increased adiposity, chronic ICV administration of NPY in conscious unstressed rats did not increase arterial pressure. Neuropeptide Y decreased heart rate, suggesting a sympathoinhibitory effect.
Obesity induced by 2-week ICV administration of NPY does not increase arterial pressure, perhaps indicating inhibition of sympathetic outflow that may oppose the pressor effect of adiposity.
Details
- Title: Subtitle
- Hemodynamic consequences of neuropeptide Y-induced obesity
- Creators
- Marcelo L.G Correia - Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USADonald A Morgan - Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USAWilliam I Sivitz - Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USAAllyn L Mark - Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USAWilliam G Haynes - Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- American journal of hypertension, Vol.15(2), pp.137-142
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0895-7061(01)02270-1
- PMID
- 11865825
- ISSN
- 0895-7061
- eISSN
- 1879-1905
- Language
- English
- Date published
- 2002
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094616602771
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