Journal article
Hemophiliacs With HIV Antibody Are Actively Infected
JAMA : the journal of the American Medical Association, Vol.260(15), pp.2236-2239
10/21/1988
DOI: 10.1001/jama.1988.03410150084035
PMID: 3139899
Abstract
Cultures of peripheral blood mononuclear cells for human immunodeficiency virus type 1 (HIV-1) and assays for the p24 antigen were performed for a group of 75 unselected hemophiliacs to determine whether patients positive for HIV-1 antibody are actively infected rather than immunized by viral proteins in non— heat-treated factor VIII or IX concentrates. Fifty-six (75%) of the 75 hemophiliacs were antibody positive and 55 (98%) of the 56 with antibodies also had positive cultures. The one culture-negative individual had detectable HIV-1 proviral DNA sequences in three separate samples of peripheral blood mononuclear cell DNA, as detected by a polymerase chain reaction assay. Detection of serum p24 antigen and the time to development of a positive culture were significantly more frequent and shorter, respectively, in symptomatic vs asymptomatic patients. None of the 19 hemophiliacs negative for HIV-1 antibody had positive cultures, detectable p24 serum antigen, or symptoms of HIV-1 infection. Moreover, latent HIV-1 infection was not detected in 16 female sexual partners of hemophiliacs positive for HIV-1 antibody using Western blot testing, assays for p24 antigen, HIV-1 cultures, and polymerase chain reaction assays, despite repeated unprotected sexual exposure. We conclude that antibody-positive hemophiliacs have been actively infected by HIV-1 and that a long period of latent HIV-1 infection prior to overt seroconversion is unlikely.(JAMA 1988;260:2236-2239)
Details
- Title: Subtitle
- Hemophiliacs With HIV Antibody Are Actively Infected
- Creators
- J. Brooks JacksonKim J SannerudJocelyn S HopsickerShirley Y KwokJ. Roger EdsonHenry H Balfour
- Resource Type
- Journal article
- Publication Details
- JAMA : the journal of the American Medical Association, Vol.260(15), pp.2236-2239
- Publisher
- American Medical Association
- DOI
- 10.1001/jama.1988.03410150084035
- PMID
- 3139899
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- Language
- English
- Date published
- 10/21/1988
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047682902771
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