Journal article
Heparin as a Therapy for Atherosclerosis: Preliminary Observations on the Intrapulmonary Administration of Low-Dose Heparin in the Morning Versus Evening Gauged by Its Effect on Blood Variables
Chronobiology international, Vol.8(3), pp.210-233
1991
DOI: 10.3109/07420529109063928
PMID: 1794159
Abstract
Reports on clinical trials with subcutaneous and intrapulmonary administration of low-dose heparin suggest that it may be an attractive therapeutic modality for the treatment of coronary artery disease because of unprecedented reduction in mortality of treated subjects. As a preliminary to a clinical trial with low-dose intrapulmonary heparin, a pilot study was conducted on three subjects. It compares overall circadian responses of 37 blood variables following intrapulmonary administration of heparin (10,500-18,800 U) in the morning (0800 h) and in the evening (2000 h). After each of these times, blood samples, mostly at 3 h intervals for the ensuing 27 h, were analyzed for heparin, APTT, TT, functional fibrinogen, CBC, enzymes, lipids, electrolytes, and hormones. Each time series was analyzed for circadian rhythm by the least-squares fit of a 24 h cosine and circadian mesors were compared by the Bingham test of rhythm parameters. Following heparin in the evening, but not in the morning, a statistically significant increase in circulating heparin levels, as well as directional increases in APTT and TT and decreases in fibrinogen, were observed in all three subjects. Same direction changes in several other variables were also observed. It is concluded that inhalation of heparin in low-dose levels results in variable circadian effects on blood parameters measured, ranging from no changes in their levels to minimal within normal range changes, and that these effects are dependent upon the timing of dose administration. It is suggested that the timed self-administration of low-dose heparin by inhalation be seriously considered for long-term clinical trials in the treatment and prevention of atherosclerosis.
Details
- Title: Subtitle
- Heparin as a Therapy for Atherosclerosis: Preliminary Observations on the Intrapulmonary Administration of Low-Dose Heparin in the Morning Versus Evening Gauged by Its Effect on Blood Variables
- Creators
- Eugene L Kanabrocki - Edward Hines, Jr. VA HospitalRobert B. Sothern - University of MinnesotaWilliam F. Bremner - Edward Hines, Jr. VA HospitalScott A. Gruber - University of MinnesotaLawrence E. Scheving - John L. ScottDavid L. Bushnell - Edward Hines, Jr. VA HospitalMay Ryan - Edward Hines, Jr. VA HospitalMyron E. Rubnitz - Edward Hines, Jr. VA HospitalNancy Fabbrini - Edward Hines, Jr. VA HospitalSandy Lampo - Edward Hines, Jr. VA HospitalCarol Cournoyer - Edward Hines, Jr. VA HospitalJane L.H.C. Third - Edward Hines, Jr. VA HospitalHunter Mermall - Edward Hines, Jr. VA HospitalHenry Ferlin - Edward Hines, Jr. VA HospitalSabera Vahed - Loyola University Medical CenterDavid L. Vesely - University of South FloridaLinda Sackett-Lundeen - Department of Pathology, St. Paul-Ramsey Medical Center/ Ramsey Clinic, St PaulErhard Haus - Department of Pathology, St. Paul-Ramsey Medical Center/ Ramsey Clinic, St PaulJohn H. Olwin - Rush University Medical Center
- Resource Type
- Journal article
- Publication Details
- Chronobiology international, Vol.8(3), pp.210-233
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/07420529109063928
- PMID
- 1794159
- ISSN
- 0742-0528
- eISSN
- 1525-6073
- Language
- English
- Date published
- 1991
- Academic Unit
- Radiology
- Record Identifier
- 9984318687602771
Metrics
26 Record Views