Journal article
Hepatectomy for Breast Cancer Metastasis and Sarcoma are more likely to have Adverse Outcomes than Hepatectomy for Primary Hepatocellular Cancer or for Colorectal Metastasis
Cancer medicine journal, Vol.3(Suppl 1), pp.6-12
07/23/2020
PMCID: PMC7664114
PMID: 33196059
Abstract
Introduction: Outcomes for hepatectomy for breast cancer metastasis and sarcomatous disease processes are not well defined in literature. We sought to use a national database to identify outcomes in these patients compared to subset of patients more well studied in literature - primary Hepatocellular cancer patients and patients with colorectal metastasis.
Methods: We identified patients undergoing major hepatectomy (≥ 3 segments) for primary hepatocellular cancer (HCC), sarcoma metastasis, breast cancer metastasis, and colorectal metastasis using NSQIP database. The Primary outcome measure was 30-day mortality. Secondary outcome measures were 30-day readmission and complication rates.
Results: A total of 5580 patients underwent major hepatectomy during the study period. Patients who underwent hepatectomy for breast cancer metastasis had higher incidence of in-hospital complications (37%) compared to sarcoma (29%), colon (26%), and HCC patients (24%) and 30-days readmission rate (37% vs. 29% - sarcoma vs. 26% - colon vs. 25% HCC). There was no difference in 30-days mortality among the groups.
Conclusion: Patients undergoing major hepatectomies for breast cancer metastasis and sarcoma are more likely to have adverse outcomes than compared to their counterparts. This difference highlights the lack of experience in managing breast cancer and sarcoma with metastatic disease to the liver. This also highlights the difference in tumor biology among all the lesions we studied. An extensive discussion should take place when dealing with breast and sarcoma lesions in the liver because of these outcomes.
Details
- Title: Subtitle
- Hepatectomy for Breast Cancer Metastasis and Sarcoma are more likely to have Adverse Outcomes than Hepatectomy for Primary Hepatocellular Cancer or for Colorectal Metastasis
- Creators
- Hassan Aziz - University of Southern CaliforniaKamil Hanna - Westchester Medical CenterMuhammad Wasif Saif - Donald & Barbara Zucker School of Medicine at Hofstra/NorthwellMuhammad Ameen Rauf - Vanderbilt University Medical CenterYuri Genyk - University of Southern CaliforniaMohd Raashid Sheikh - University of Southern California
- Resource Type
- Journal article
- Publication Details
- Cancer medicine journal, Vol.3(Suppl 1), pp.6-12
- PMID
- 33196059
- PMCID
- PMC7664114
- Language
- English
- Date published
- 07/23/2020
- Academic Unit
- Surgery
- Record Identifier
- 9984701841002771
Metrics
2 Record Views