Journal article
Hepatic microsomal enzyme induction by 2, 2', 3, 3', 4, 4'- and 2, 2', 3', 4, 4', 5-hexachlorobiphenyl
Life sciences (1973), Vol.27(24), pp.2333-2337
1980
DOI: 10.1016/0024-3205(80)90502-0
PMID: 6782406
Abstract
In an attempt to resolve conflicting reports in the literature, the effects of 2, 2', 3, 3', 4, 4'-hexa- and 2, 2', 3', 4, 4', 5-hexachlorobiphenyl on the hepatic microsomal drug-metabolizing enzymes were evaluated in the immature male rat. By comparison with the effects of the classical enzyme inducers, phenobarbitone (PB) and 3-methylcholanthrene (MC), 2, 2', 3, 3', 4, 4'-hexachlorobiphenyl, irrespective of its synthetic route, exhibited PB- and MC-type characteristics; the most prominent feature of the latter being a seven-fold increase in 4-chlorobiphenyl hydroxylase activity. 2, 2', 3', 4, 4', 5-Hexachlorobiphenyl also resembled a mixed (PB + MC)-type inducer although its MC-type characteristics were more pronounced than those of 2, 2', 3, 3', 4, 4'-hexachlorobiphenyl.
Details
- Title: Subtitle
- Hepatic microsomal enzyme induction by 2, 2', 3, 3', 4, 4'- and 2, 2', 3', 4, 4', 5-hexachlorobiphenyl
- Creators
- A. Parkinson - University of GuelphL.W. RobertsonS. Safe - University of Guelph
- Resource Type
- Journal article
- Publication Details
- Life sciences (1973), Vol.27(24), pp.2333-2337
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0024-3205(80)90502-0
- PMID
- 6782406
- ISSN
- 0024-3205
- eISSN
- 1879-0631
- Language
- English
- Date published
- 1980
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984364454002771
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