Journal article
Hepatitis A virus-specific humoral and cellular immune responses following immunization with a formalin-inactivated hepatitis A vaccine
Vaccine, Vol.18(9), pp.892-898
1999
DOI: 10.1016/S0264-410X(99)00342-4
PMID: 10580203
Abstract
To evaluate proliferative T cell responses elicited by a formalin-inactivated HAV vaccine, we immunized 10 subjects with an inactivated HAV vaccine, and measured HAV antibody titers and HAV-specific T cell proliferation. γ-Interferon production by PBMC's was evaluated in selected subjects. By week 30, seroconversion (geometric mean titer=2299 mIU/ml), and HAV-specific proliferation was detected in all subjects. HAV also induced γ-interferon in the three subjects studied. These data indicate that the inactivated HAV vaccine induces proliferative T cell responses in addition to HAV antibody. This may be important for protection against hepatitis A, and suggests that recall memory for HAV antigen is elicited by the vaccine.
Details
- Title: Subtitle
- Hepatitis A virus-specific humoral and cellular immune responses following immunization with a formalin-inactivated hepatitis A vaccine
- Creators
- J.B Cederna - Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Dr. (SW54 GH), Iowa City, IA 52242, USAD Klinzman - Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Dr. (SW54 GH), Iowa City, IA 52242, USAJ.T Stapleton - Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Dr. (SW54 GH), Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Vaccine, Vol.18(9), pp.892-898
- DOI
- 10.1016/S0264-410X(99)00342-4
- PMID
- 10580203
- NLM abbreviation
- Vaccine
- ISSN
- 0264-410X
- eISSN
- 1873-2518
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 1999
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094514302771
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