Journal article
Hepatitis C Increases the Risk of Progression of Chronic Kidney Disease in Patients with Glomerulonephritis
American journal of nephrology, Vol.32(4), pp.311-316
10/2010
DOI: 10.1159/000319456
PMCID: PMC2969148
PMID: 20714136
Abstract
Background/aims: We have shown that hepatitis C does not increase the risk of developing chronic kidney disease (CKD), but it is not known if hepatitis C worsens progression of existing CKD.
Methods: We retrospectively identified patients with primary glomerulonephritis on biopsy over 4 years, evaluating the progression of CKD over time.
Results: The cohort consisted of 111 patients: 21% were positive for hepatitis C, 61% were negative for hepatitis C and 18% were not tested. The hepatitis C-positive subjects were more likely to be African American (p = 0.031), followed for fewer days (p = 0.007) and have diabetes and focal segmental glomerulosclerosis on biopsy (p < 0.001). Longitudinal follow-up of CKD progression using multiple creatinine measures analyzed by repeated measures ANCOVA demonstrated that patients with hepatitis C had a worsening creatinine over time compared to the hepatitis C-negative and not tested groups (p < 0.001). By Cox hazards regression analyses, risk of death/end-stage renal disease (ESRD) was decreased in patients who tested negative for hepatitis C compared to testing positive (0.46, CI 0.27-0.88), but this became nonsignificant after adjustment for mean arterial pressure and hemoglobin.
Conclusion: Our results support that infection with hepatitis C in patients with glomerulonephritis is associated with an increased risk of progression of CKD. Prospective studies are required to confirm these observations.
Details
- Title: Subtitle
- Hepatitis C Increases the Risk of Progression of Chronic Kidney Disease in Patients with Glomerulonephritis
- Creators
- Lama A Noureddine - Indiana University School of Medicine, Indianapolis, Ind., USASohail A Usman - Indiana University School of Medicine, Indianapolis, Ind., USAZhangsheng Yu - Indiana University School of Medicine, Indianapolis, Ind., USARanjani N Moorthi - Indiana University School of Medicine, Indianapolis, Ind., USASharon M Moe - Indiana University School of Medicine, Indianapolis, Ind., USA
- Resource Type
- Journal article
- Publication Details
- American journal of nephrology, Vol.32(4), pp.311-316
- Publisher
- S. Karger AG
- DOI
- 10.1159/000319456
- PMID
- 20714136
- PMCID
- PMC2969148
- ISSN
- 0250-8095
- eISSN
- 1421-9670
- Language
- English
- Date published
- 10/2010
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094405302771
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