Journal article
Hepatitis C virus viremia in HIV-infected individuals with negative HCV antibody tests
Journal of acquired immune deficiency syndromes (1999), Vol.31(2), pp.154-162
2002
DOI: 10.1097/00126334-200210010-00005
PMID: 12394793
Abstract
Hepatitis C virus (HCV) viremia may occur in persons without detectable HCV antibodies and has been reported in as many as 5.5% of HIV-positive persons. To better characterize serosilent HCV infection, the authors prospectively tested 131 HIV-positive persons and 102 HIV-negative control subjects with diabetes for the presence of HCV antibody (Ab) and HCV RNA. Thirty of 31 HCV Ab-positive (AbP) HIV-positive people tested positive for HCV RNA as did both HCV AbP, HIV-negative control subjects. Similarly, none of the 100 HIV-negative, HCV Ab-negative (AbN) control subjects was HCV RNA positive (p<.001). In contrast, 19 of 100 HIV-positive, HCV AbN persons met stringent criteria for HCV viremia, and 9 of these 19 people were HCV RNA positive when tested by a commercially available HCV RNA detection method. The mean duration of HCV viremia in HCV AbN people was 26.8 months (range, 1-99 months). None of the subjects developed HCV antibody during the study. The HIV-positive, HCV AbP, and RNA-positive group was significantly more likely to have acquired HIV parenterally (p<.001), have higher initial CD4 counts (p=.029), and have higher ALT values than the HCV AbN group (p<.002). In summary, HCV infection appears to occur more frequently among HIV-infected, HCV-seronegative persons than appreciated, especially if HIV acquisition was through sexual as opposed to parenteral risk factors and was associated with a lower initial CD4 count and lower ALT values.
Details
- Title: Subtitle
- Hepatitis C virus viremia in HIV-infected individuals with negative HCV antibody tests
- Creators
- Sarah L GEORGE - Departments of Internal Medicine and Research, Iowa City Veterans Administration Medical Center and The University of Iowa College of Medicine, Iowa City, Iowa, United StatesJenny GEBHARDT - Departments of Internal Medicine and Research, Iowa City Veterans Administration Medical Center and The University of Iowa College of Medicine, Iowa City, Iowa, United StatesDonna KLINZMAN - Departments of Internal Medicine and Research, Iowa City Veterans Administration Medical Center and The University of Iowa College of Medicine, Iowa City, Iowa, United StatesMathew B FOSTER - Departments of Internal Medicine and Research, Iowa City Veterans Administration Medical Center and The University of Iowa College of Medicine, Iowa City, Iowa, United StatesKevin D PATRICK - Departments of Internal Medicine and Research, Iowa City Veterans Administration Medical Center and The University of Iowa College of Medicine, Iowa City, Iowa, United StatesWarren N SCHMIDT - Departments of Internal Medicine and Research, Iowa City Veterans Administration Medical Center and The University of Iowa College of Medicine, Iowa City, Iowa, United StatesBeth ALDEN - Departments of Internal Medicine and Research, Iowa City Veterans Administration Medical Center and The University of Iowa College of Medicine, Iowa City, Iowa, United StatesMichael A PFALLER - Departments of Internal Medicine and Research, Iowa City Veterans Administration Medical Center and The University of Iowa College of Medicine, Iowa City, Iowa, United StatesJack T STAPLETON - Departments of Internal Medicine and Research, Iowa City Veterans Administration Medical Center and The University of Iowa College of Medicine, Iowa City, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- Journal of acquired immune deficiency syndromes (1999), Vol.31(2), pp.154-162
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/00126334-200210010-00005
- PMID
- 12394793
- ISSN
- 1525-4135
- eISSN
- 1944-7884
- Language
- English
- Date published
- 2002
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Epidemiology; Gastroenterology and Hepatology; Pathology; Internal Medicine
- Record Identifier
- 9984094647702771
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